2010 French SPILF-AFSSAPS guiding criteria for Streptococcuspneumoniae acute community-acquired pneumonia: Evaluation in patients of the PACSCAN-ESCAPED cohort

• Published in: Infectious diseases now (Online) 2021-03, Vol.51 (2), p.146-152
• Main Authors: Ben Hayoun, M., Tubiana, S., Varon, E., Naccache, J.M., Le Floch, H., Leport, C., Claessens, Y.E., Duval, X.
• Format: Article
• Language: English
• Subjects: Community-acquired pneumonia; Streptococcuspneumoniae
• ISSN: 2666-9919; 2666-9919
• DOI: 10.1016/j.medmal.2020.09.004

•The 2010 SPILF-AFSSAPS guiding criteria defining Streptococcuspneumoniae acute community-acquired pneumonia (CAP) are open to broad interpretation by physicians.•These criteria were observed in 2–100% of patients presenting with a suspicion of CAP at the emergency departments of four Parisian university hospitals.•As such, these criteria are inadequate to precisely guide physicians towards pneumococcal etiology. To assess the proportion of patients meeting the 2010 SPILF-AFSSAPS guiding criteria for Streptococcuspneumoniae in patients consulting at the emergency departments of four French university hospitals for acute community-acquired pneumonia (CAP) suspicion. The PACSCAN study prospectively included 319 patients. Medical history, clinical, biological, and radiological presentations were collected. An adjudication committee retrospectively classified the diagnostic certainty based on the initial chest CT scan data and the follow-up data up to Day 28. S. pneumoniae was looked for according to the clinician's choice of blood culture, pneumococcal urinary antigen test, nasopharyngeal PCR, and/or sputum microbiological examination. All patients (100%) met at least one criterion for S. pneumoniae CAP and six (2%) met all criteria. The distribution of criteria ranged from 32% (chest pain criterion) to 86% (age≥40years criterion). These figures were respectively 100%, 3%, 38%, and 82% when the study population was restricted to the 139 patients with definite or probable CAP, according to the adjudication committee. Taking into account the microbiological results, the criteria taken one by one or combined did not make it possible to differentiate the 19 S. pneumoniae CAP from the other CAPs. The 2010 SPILF-AFSSAPS guiding criteria for S. pneumoniae CAP are found in very variable proportions and do not, in their current form, make it possible to accurately guide towards a pneumococcal etiology in patients included in the PACSCAN study.