Loading…
Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study
Purpose Well-differentiated liposarcoma, the most common subtype of liposarcoma, should be discriminated from benign lipoma. However, features on sonography for discriminating these two types of tumor have not been fully investigated. The present study was therefore aimed at clarifying differences i...
Saved in:
| Published in: | Journal of medical ultrasonics (2001) 2020-10, Vol.47 (4), p.617-623 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13 |
| container_end_page | 623 |
| container_issue | 4 |
| container_start_page | 617 |
| container_title | Journal of medical ultrasonics (2001) |
| container_volume | 47 |
| creator | Shimamori, Naoko Kishino, Tomonori Okabe, Naota Morii, Takeshi Matsushima, Satsuki Yamasaki, Satoko Ohtsuka, Kouki Shibahara, Junji Ohnishi, Hiroaki Watanabe, Takashi |
| description | Purpose
Well-differentiated liposarcoma, the most common subtype of liposarcoma, should be discriminated from benign lipoma. However, features on sonography for discriminating these two types of tumor have not been fully investigated. The present study was therefore aimed at clarifying differences in sonographic findings between well-differentiated liposarcoma and lipoma.
Methods
The study population comprised 23 cases of well-differentiated liposarcoma and 181 cases of lipoma. We investigated differences in sonographic appearance and pathological findings between the two types of tumor.
Results
Well-differentiated liposarcoma tended to develop more frequently in older patients and in the lower extremities including the gluteal region, compared with lipoma. Concerning sonographic findings, both tumors exhibited well-defined margins and heterogeneous internal echogenicity, including typical tiny striated hyperechoic lines. Well-differentiated liposarcoma was characterized by a higher frequency of the following findings compared with lipoma: (1) deep location, (2) irregular shape, (3) large diameter, (4) hyperechogenicity compared to surrounding tissue, and (5) presence of vascularity on Doppler sonography (
p
|
| doi_str_mv | 10.1007/s10396-020-01051-5 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2444877227</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714887510</galeid><sourcerecordid>A714887510</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS1ERcvCF-CAInHpJcV_E4dbVQpUqtQLnC3HHi-uEjvYDtV-e7zdQgWqOHk0fm_0Zn4IvSH4jGDcv88Es6FrMcUtJliQVjxDJ6QjrKVU8Oe1ZrxruaDsGL3M-RZjzjimL9Axo0OHmRQn6O6jzyb52QddfAxNdM0dTFNrvXOQIBSvC9hm8kvMOpk468alODcjBL8N9_3aqsYcQ9wmvXzffWh0aNZgYigpTlN1J6hVXsAU_xOaXFa7e4WOnJ4yvH54N-jbp8uvF1_a65vPVxfn160RjJZ2NM51TMhREzZiwo0EKzQDarQFLsVoqegMsdBza3prNceacqMH29uBA2EbdHqYu6T4Y4Vc1FwXrhvqAHHNinLOZd9T2lfpu3-kt3FNoaZTdCCSSDnQ4VG11RMoH1wsSZv9UHXeEy5lLyqWDTp7QqX3qWdfLwPO1_5fBnowmHqpnMCppVLRaacIVnva6kBbVdrqnrYS1fT2IfE6zmD_WH7jrQJ2EOT6FbaQHlf6z9hfdcK26A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918188929</pqid></control><display><type>article</type><title>Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study</title><source>Springer Nature</source><creator>Shimamori, Naoko ; Kishino, Tomonori ; Okabe, Naota ; Morii, Takeshi ; Matsushima, Satsuki ; Yamasaki, Satoko ; Ohtsuka, Kouki ; Shibahara, Junji ; Ohnishi, Hiroaki ; Watanabe, Takashi</creator><creatorcontrib>Shimamori, Naoko ; Kishino, Tomonori ; Okabe, Naota ; Morii, Takeshi ; Matsushima, Satsuki ; Yamasaki, Satoko ; Ohtsuka, Kouki ; Shibahara, Junji ; Ohnishi, Hiroaki ; Watanabe, Takashi</creatorcontrib><description>Purpose
Well-differentiated liposarcoma, the most common subtype of liposarcoma, should be discriminated from benign lipoma. However, features on sonography for discriminating these two types of tumor have not been fully investigated. The present study was therefore aimed at clarifying differences in sonographic findings between well-differentiated liposarcoma and lipoma.
Methods
The study population comprised 23 cases of well-differentiated liposarcoma and 181 cases of lipoma. We investigated differences in sonographic appearance and pathological findings between the two types of tumor.
Results
Well-differentiated liposarcoma tended to develop more frequently in older patients and in the lower extremities including the gluteal region, compared with lipoma. Concerning sonographic findings, both tumors exhibited well-defined margins and heterogeneous internal echogenicity, including typical tiny striated hyperechoic lines. Well-differentiated liposarcoma was characterized by a higher frequency of the following findings compared with lipoma: (1) deep location, (2) irregular shape, (3) large diameter, (4) hyperechogenicity compared to surrounding tissue, and (5) presence of vascularity on Doppler sonography (
p
< 0.01 each). Notably, hyperechogenicity corresponded to the intermingled sclerosing component within the adipocytic component when sonographic findings were compared with those of pathology.
Conclusion
The present study suggests that several sonographic findings including hyperechogenicity and presence of vascularity might be key features for discriminating well-differentiated liposarcoma from lipoma.</description><identifier>ISSN: 1346-4523</identifier><identifier>EISSN: 1613-2254</identifier><identifier>DOI: 10.1007/s10396-020-01051-5</identifier><identifier>PMID: 32960385</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adult ; Age Distribution ; Aged ; Buttocks - diagnostic imaging ; Buttocks - pathology ; Calcification ; Chi-square test ; Comparative analysis ; Connective tissue tumors ; Diagnosis, Differential ; Female ; Histopathology ; Humans ; Imaging ; Lipoma - diagnostic imaging ; Liposarcoma ; Liposarcoma - diagnostic imaging ; Liposarcoma - pathology ; Male ; Margins of Excision ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Original Article–Orthopedics ; Radiology ; Retrospective Studies ; Tumors ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Ultrasound imaging</subject><ispartof>Journal of medical ultrasonics (2001), 2020-10, Vol.47 (4), p.617-623</ispartof><rights>The Japan Society of Ultrasonics in Medicine 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Japan Society of Ultrasonics in Medicine 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13</citedby><cites>FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13</cites><orcidid>0000-0003-3970-9781</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32960385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimamori, Naoko</creatorcontrib><creatorcontrib>Kishino, Tomonori</creatorcontrib><creatorcontrib>Okabe, Naota</creatorcontrib><creatorcontrib>Morii, Takeshi</creatorcontrib><creatorcontrib>Matsushima, Satsuki</creatorcontrib><creatorcontrib>Yamasaki, Satoko</creatorcontrib><creatorcontrib>Ohtsuka, Kouki</creatorcontrib><creatorcontrib>Shibahara, Junji</creatorcontrib><creatorcontrib>Ohnishi, Hiroaki</creatorcontrib><creatorcontrib>Watanabe, Takashi</creatorcontrib><title>Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study</title><title>Journal of medical ultrasonics (2001)</title><addtitle>J Med Ultrasonics</addtitle><addtitle>J Med Ultrason (2001)</addtitle><description>Purpose
Well-differentiated liposarcoma, the most common subtype of liposarcoma, should be discriminated from benign lipoma. However, features on sonography for discriminating these two types of tumor have not been fully investigated. The present study was therefore aimed at clarifying differences in sonographic findings between well-differentiated liposarcoma and lipoma.
Methods
The study population comprised 23 cases of well-differentiated liposarcoma and 181 cases of lipoma. We investigated differences in sonographic appearance and pathological findings between the two types of tumor.
Results
Well-differentiated liposarcoma tended to develop more frequently in older patients and in the lower extremities including the gluteal region, compared with lipoma. Concerning sonographic findings, both tumors exhibited well-defined margins and heterogeneous internal echogenicity, including typical tiny striated hyperechoic lines. Well-differentiated liposarcoma was characterized by a higher frequency of the following findings compared with lipoma: (1) deep location, (2) irregular shape, (3) large diameter, (4) hyperechogenicity compared to surrounding tissue, and (5) presence of vascularity on Doppler sonography (
p
< 0.01 each). Notably, hyperechogenicity corresponded to the intermingled sclerosing component within the adipocytic component when sonographic findings were compared with those of pathology.
Conclusion
The present study suggests that several sonographic findings including hyperechogenicity and presence of vascularity might be key features for discriminating well-differentiated liposarcoma from lipoma.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Buttocks - diagnostic imaging</subject><subject>Buttocks - pathology</subject><subject>Calcification</subject><subject>Chi-square test</subject><subject>Comparative analysis</subject><subject>Connective tissue tumors</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Lipoma - diagnostic imaging</subject><subject>Liposarcoma</subject><subject>Liposarcoma - diagnostic imaging</subject><subject>Liposarcoma - pathology</subject><subject>Male</subject><subject>Margins of Excision</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Original Article–Orthopedics</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Ultrasound imaging</subject><issn>1346-4523</issn><issn>1613-2254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS1ERcvCF-CAInHpJcV_E4dbVQpUqtQLnC3HHi-uEjvYDtV-e7zdQgWqOHk0fm_0Zn4IvSH4jGDcv88Es6FrMcUtJliQVjxDJ6QjrKVU8Oe1ZrxruaDsGL3M-RZjzjimL9Axo0OHmRQn6O6jzyb52QddfAxNdM0dTFNrvXOQIBSvC9hm8kvMOpk468alODcjBL8N9_3aqsYcQ9wmvXzffWh0aNZgYigpTlN1J6hVXsAU_xOaXFa7e4WOnJ4yvH54N-jbp8uvF1_a65vPVxfn160RjJZ2NM51TMhREzZiwo0EKzQDarQFLsVoqegMsdBza3prNceacqMH29uBA2EbdHqYu6T4Y4Vc1FwXrhvqAHHNinLOZd9T2lfpu3-kt3FNoaZTdCCSSDnQ4VG11RMoH1wsSZv9UHXeEy5lLyqWDTp7QqX3qWdfLwPO1_5fBnowmHqpnMCppVLRaacIVnva6kBbVdrqnrYS1fT2IfE6zmD_WH7jrQJ2EOT6FbaQHlf6z9hfdcK26A</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Shimamori, Naoko</creator><creator>Kishino, Tomonori</creator><creator>Okabe, Naota</creator><creator>Morii, Takeshi</creator><creator>Matsushima, Satsuki</creator><creator>Yamasaki, Satoko</creator><creator>Ohtsuka, Kouki</creator><creator>Shibahara, Junji</creator><creator>Ohnishi, Hiroaki</creator><creator>Watanabe, Takashi</creator><general>Springer Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3970-9781</orcidid></search><sort><creationdate>20201001</creationdate><title>Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study</title><author>Shimamori, Naoko ; Kishino, Tomonori ; Okabe, Naota ; Morii, Takeshi ; Matsushima, Satsuki ; Yamasaki, Satoko ; Ohtsuka, Kouki ; Shibahara, Junji ; Ohnishi, Hiroaki ; Watanabe, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Buttocks - diagnostic imaging</topic><topic>Buttocks - pathology</topic><topic>Calcification</topic><topic>Chi-square test</topic><topic>Comparative analysis</topic><topic>Connective tissue tumors</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Lipoma - diagnostic imaging</topic><topic>Liposarcoma</topic><topic>Liposarcoma - diagnostic imaging</topic><topic>Liposarcoma - pathology</topic><topic>Male</topic><topic>Margins of Excision</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Original Article–Orthopedics</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Ultrasound imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimamori, Naoko</creatorcontrib><creatorcontrib>Kishino, Tomonori</creatorcontrib><creatorcontrib>Okabe, Naota</creatorcontrib><creatorcontrib>Morii, Takeshi</creatorcontrib><creatorcontrib>Matsushima, Satsuki</creatorcontrib><creatorcontrib>Yamasaki, Satoko</creatorcontrib><creatorcontrib>Ohtsuka, Kouki</creatorcontrib><creatorcontrib>Shibahara, Junji</creatorcontrib><creatorcontrib>Ohnishi, Hiroaki</creatorcontrib><creatorcontrib>Watanabe, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical ultrasonics (2001)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimamori, Naoko</au><au>Kishino, Tomonori</au><au>Okabe, Naota</au><au>Morii, Takeshi</au><au>Matsushima, Satsuki</au><au>Yamasaki, Satoko</au><au>Ohtsuka, Kouki</au><au>Shibahara, Junji</au><au>Ohnishi, Hiroaki</au><au>Watanabe, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study</atitle><jtitle>Journal of medical ultrasonics (2001)</jtitle><stitle>J Med Ultrasonics</stitle><addtitle>J Med Ultrason (2001)</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>47</volume><issue>4</issue><spage>617</spage><epage>623</epage><pages>617-623</pages><issn>1346-4523</issn><eissn>1613-2254</eissn><abstract>Purpose
Well-differentiated liposarcoma, the most common subtype of liposarcoma, should be discriminated from benign lipoma. However, features on sonography for discriminating these two types of tumor have not been fully investigated. The present study was therefore aimed at clarifying differences in sonographic findings between well-differentiated liposarcoma and lipoma.
Methods
The study population comprised 23 cases of well-differentiated liposarcoma and 181 cases of lipoma. We investigated differences in sonographic appearance and pathological findings between the two types of tumor.
Results
Well-differentiated liposarcoma tended to develop more frequently in older patients and in the lower extremities including the gluteal region, compared with lipoma. Concerning sonographic findings, both tumors exhibited well-defined margins and heterogeneous internal echogenicity, including typical tiny striated hyperechoic lines. Well-differentiated liposarcoma was characterized by a higher frequency of the following findings compared with lipoma: (1) deep location, (2) irregular shape, (3) large diameter, (4) hyperechogenicity compared to surrounding tissue, and (5) presence of vascularity on Doppler sonography (
p
< 0.01 each). Notably, hyperechogenicity corresponded to the intermingled sclerosing component within the adipocytic component when sonographic findings were compared with those of pathology.
Conclusion
The present study suggests that several sonographic findings including hyperechogenicity and presence of vascularity might be key features for discriminating well-differentiated liposarcoma from lipoma.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32960385</pmid><doi>10.1007/s10396-020-01051-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3970-9781</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-4523 |
| ispartof | Journal of medical ultrasonics (2001), 2020-10, Vol.47 (4), p.617-623 |
| issn | 1346-4523 1613-2254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2444877227 |
| source | Springer Nature |
| subjects | Adult Age Distribution Aged Buttocks - diagnostic imaging Buttocks - pathology Calcification Chi-square test Comparative analysis Connective tissue tumors Diagnosis, Differential Female Histopathology Humans Imaging Lipoma - diagnostic imaging Liposarcoma Liposarcoma - diagnostic imaging Liposarcoma - pathology Male Margins of Excision Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Original Article–Orthopedics Radiology Retrospective Studies Tumors Ultrasonic imaging Ultrasonography - methods Ultrasound Ultrasound imaging |
| title | Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T14%3A40%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discrimination%20of%20well-differentiated%20liposarcoma%20from%20benign%20lipoma%20on%20sonography:%20an%20uncontrolled%20retrospective%20study&rft.jtitle=Journal%20of%20medical%20ultrasonics%20(2001)&rft.au=Shimamori,%20Naoko&rft.date=2020-10-01&rft.volume=47&rft.issue=4&rft.spage=617&rft.epage=623&rft.pages=617-623&rft.issn=1346-4523&rft.eissn=1613-2254&rft_id=info:doi/10.1007/s10396-020-01051-5&rft_dat=%3Cgale_proqu%3EA714887510%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c532t-bcff6358ba13b014c8ed5a3e2cade485bd256c1de74dc7dda40a24ca9d7d94e13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2918188929&rft_id=info:pmid/32960385&rft_galeid=A714887510&rfr_iscdi=true |