In vitro effects of Moringa oleifera seed lectins on Haemonchus contortus in larval and adult stages

Haemonchus contortus is a hematophagous parasite causing damage to the production of ruminant animals throughout the world. This study evaluated the in vitro effect of proteins from Moringa oleifera (WSMoL - Water Soluble M. oleifera Lectin and cMoL - coagulant M. oleifera Lectin) on the motility of...

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Bibliographic Details
Published in:Experimental parasitology 2020-11, Vol.218, p.108004-108004, Article 108004
Main Authors: Medeiros, Mário L.S., Alves, Robson R.V., Oliveira, Benny F., Napoleão, Thiago H., Paiva, Patrícia M.G., Coelho, Luana C.B.B., Bezerra, Ana C.D.S., Silva, Michele D.C.
Format: Article
Language:English
Subjects:
Lectin
Moringa oleifera
Motility index
Nematode
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Summary:Haemonchus contortus is a hematophagous parasite causing damage to the production of ruminant animals throughout the world. This study evaluated the in vitro effect of proteins from Moringa oleifera (WSMoL - Water Soluble M. oleifera Lectin and cMoL - coagulant M. oleifera Lectin) on the motility of infective larvae and adult male and female worms of H. contortus. The specific activity of total proteases and the morphology of the worms exposed to the lectins were observed. Both lectins inhibited motility of all parasite stages tested. WSMoL and cMoL at 500 μg mL−1 interfered in the motility of larvae. Values of 11.1% and 8.1% were the lowest motility indices of larvae with sheath, and 30.6% and 16.4% were the lowest motility indices of exsheathed larvae treated with WSMoL and cMoL, respectively. In 1 mg mL−1 solutions of WSMoL and of cMoL, the motility index of adult male worms was 23.3% (p 
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2020.108004