Roles and mechanisms of MFG-E8 in vascular aging-related diseases

•It is indispensable to clarify the mechanisms underlying vascular aging because of the increasingly prominent related diseases.•Alterations in structural properties and the biological functions of ECs and VSMCs are the major causes of vascular aging.•MFG-E8 plays an important role in modulating vas...

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Bibliographic Details
Published in:Ageing research reviews 2020-12, Vol.64, p.101176-101176, Article 101176
Main Authors: Ni, Yu-Qing, Zhan, Jun-Kun, Liu, You-Shuo
Format: Article
Language:English
Subjects:
Aging
Antigens, Surface
Diseases
Endothelial Cells
Factor VIII
Glycolipids
Glycoproteins
Humans
Lipid Droplets
MFG-E8
Milk Proteins
Vascular aging
Vascular smooth muscle cells
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Summary:•It is indispensable to clarify the mechanisms underlying vascular aging because of the increasingly prominent related diseases.•Alterations in structural properties and the biological functions of ECs and VSMCs are the major causes of vascular aging.•MFG-E8 plays an important role in modulating vascular aging and the initiation and progression of vascular aging-related diseases.•MFG-E8 presents a promising prognostic biomarker and a potential therapeutic strategy to intervene vascular aging-related diseases. The aging of the vasculature plays a crucial role in the pathological progression of various vascular aging-related diseases. As endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are essential parts in the inner and medial layers of vessel wall, respectively, the structural and functional alterations of ECs and VSMCs are the major causes of vascular aging. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a multifunctional glycoprotein which exerts a regulatory role in the intercellular interactions involved in a variety of biological and pathological processes. Emerging evidence suggests that MFG-E8 is a novel and outstanding modulator for vascular aging via targeting at ECs and VSMCs. In this review, we will summarise the cumulative roles and mechanisms of MFG-E8 in vascular aging and vascular aging-related diseases with special emphasis on the functions of ECs and VSMCs. In addition, we also aim to focus on the promising diagnostic function as a biomarker and the potential therapeutic application of MFG-E8 in vascular aging and the clinical evaluation of vascular aging-related diseases.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2020.101176