Bone Tissue Composition in Postmenopausal Women Varies With Glycemic Control From Normal Glucose Tolerance to Type 2 Diabetes Mellitus

ABSTRACT The risk of fragility fracture increases for people with type 2 diabetes mellitus (T2DM), even after controlling for bone mineral density, body mass index, visual impairment, and falls. We hypothesize that progressive glycemic derangement alters microscale bone tissue composition. We used F...

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Bibliographic Details
Published in:Journal of bone and mineral research 2021-02, Vol.36 (2), p.334-346
Main Authors: Hunt, Heather B, Miller, Nicholas A, Hemmerling, Kimberly J, Koga, Maho, Lopez, Kelsie A, Taylor, Erik A, Sellmeyer, Deborah E, Moseley, Kendall F, Donnelly, Eve
Format: Article
Language:English
Subjects:
Age
Biochemical markers
BIOCHEMICAL MARKERS OF BONE TURNOVER
Body mass index
Bone composition
Bone imaging
Bone mass
Bone mineral content
Bone mineral density
Bone turnover
Bones
Collagen
Cortical bone
Crystallinity
Diabetes
Diabetes mellitus (non-insulin dependent)
FRACTURE RISK
Glucose
Glucose tolerance
Iliac crest
Insulin
Mechanical properties
Pentosidine
Post-menopause
POSTMENOPAUSAL WOMEN
Statistical analysis
TYPE 2 DIABETES MELLITUS
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Summary:ABSTRACT The risk of fragility fracture increases for people with type 2 diabetes mellitus (T2DM), even after controlling for bone mineral density, body mass index, visual impairment, and falls. We hypothesize that progressive glycemic derangement alters microscale bone tissue composition. We used Fourier‐transform infrared (FTIR) imaging to analyze the composition of iliac crest biopsies from cohorts of postmenopausal women characterized by oral glucose tolerance testing: normal glucose tolerance (NGT; n = 35, age = 65 ± 7 years, HbA1c = 5.8 ± 0.3%), impaired glucose tolerance (IGT; n = 26, age = 64 ± 5 years, HbA1c = 6.0 ± 0.4%), and overt T2DM on insulin (n = 25, age = 64 ± 6 years, HbA1c = 9.13 ± 0.6). The distributions of cortical bone mineral content had greater mean values (+7%) and were narrower (−10%) in T2DM versus NGT groups (p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.4186