Increased lipolysis after infusion of acylated ghrelin: a randomized, double‐blinded placebo‐controlled trial in hypopituitary patients

Context Acylated ghrelin increases growth hormone (GH) and adrenocorticotrophic hormone (ACTH) secretion from the anterior pituitary gland. Additionally, it increases free fatty acid levels independently of GH and ACTH, but the impact of ghrelin on fatty acid turnover has not been determined. This s...

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Published in:Clinical endocrinology (Oxford) 2020-12, Vol.93 (6), p.672-677
Main Authors: Lauritzen, Esben Stistrup, Jørgensen, Jens Otto Lunde, Møller, Niels, Nielsen, Søren, Vestergaard, Esben Thyssen
Format: Article
Language:English
Subjects:
acyl ghrelin
acylated ghrelin
Adrenocorticotropic hormone
Cross-Over Studies
Double-Blind Method
Fatty acids
Ghrelin
Glucose Clamp Technique
Growth Hormone
Growth hormones
Humans
Hydrocortisone
Lipolysis
palmitate turnover
Palmitic acid
Pituitary (anterior)
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Summary:Context Acylated ghrelin increases growth hormone (GH) and adrenocorticotrophic hormone (ACTH) secretion from the anterior pituitary gland. Additionally, it increases free fatty acid levels independently of GH and ACTH, but the impact of ghrelin on fatty acid turnover has not been determined. This study was designed to test whether acylated ghrelin directly increases the turnover rate of fatty acids. Design Eight hypopituitary patients on stable replacement with GH and hydrocortisone were included in a randomized, double‐blinded, placebo‐controlled crossover study including two study days: (a) infusion of acylated ghrelin and (b) infusion of saline. The study day comprised a basal period (t = 0‐120 minutes) and a hyperinsulinaemic‐euglycemic clamp period (t = 120‐300 minutes). Whole‐body lipolysis was estimated at t = 90‐120 and t = 270‐300 minutes with a palmitate isotope dilution technique. Results Infusion of acylated ghrelin resulted in 10 times increased total ghrelin area under the curve (AUC) levels in the basal period and 15 times increased AUC levels in the clamp period compared with saline infusion (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14290