Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples

Long non-coding RNAs (lncRNAs) have been vastly investigated for their critical roles in the pathogenesis of breast cancer. Yet, the expression pattern and clinical significance of three lncRNAs namely CTBP1AS2, LINC-ROR and SPRY4-IT1 in breast cancer are not completely clarified. In the present inv...

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Bibliographic Details
Published in:Experimental and molecular pathology 2020-12, Vol.117, p.104544-104544, Article 104544
Main Authors: Mohebi, Mehdi, Sattari, Ali, Ghafouri-Fard, Soudeh, Modarressi, Mohammad Hossein, Kholghi-Oskooei, Vahid, Taheri, Mohammad
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell Line, Tumor
Cell Proliferation - genetics
CTBP1AS2
Female
Gene Expression Regulation, Neoplastic
Humans
LINC-ROR
Middle Aged
RNA, Long Noncoding - genetics
SPRY-IT1
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Summary:Long non-coding RNAs (lncRNAs) have been vastly investigated for their critical roles in the pathogenesis of breast cancer. Yet, the expression pattern and clinical significance of three lncRNAs namely CTBP1AS2, LINC-ROR and SPRY4-IT1 in breast cancer are not completely clarified. In the present investigation, we assessed expression of these lncRNAs in breast cancer tissues and paired non-cancerous specimens from the same patients using quantitative real time PCR. Notably, expression of CTBP1AS2, LINC-ROR and SPRY4-IT1 were upregulated in breast cancer tissues compared with non-cancerous tissues (ER = 17.62, P value
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2020.104544