Prenatal predictors of motor function in children with open spina bifida: a retrospective cohort study

Objective To identify predictors for intact motor function (MF) at birth and at 12 months of life in babies with prenatally versus postnatally repaired open spina bifida (OSB). Design Retrospective cohort study. Setting Texas Children's Hospital, 2011–2018. Population Patients who underwent eit...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2021-01, Vol.128 (2), p.384-391
Main Authors: Corroenne, R, Yepez, M, Pyarali, M, Johnson, RM, Whitehead, WE, Castillo, HA, Castillo, J, Mehollin‐Ray, AR, Espinoza, J, Shamshirsaz, AA, Nassr, AA, Belfort, MA, Cortes, MS
Format: Article
Language:English
Subjects:
Ankle
Birth
Child development
Children
Cohort analysis
Female
Fetal Diseases - diagnostic imaging
Fetal Diseases - physiopathology
Fetal Diseases - surgery
Fetal surgery
Fetoscopy
Fetuses
Gestation
Humans
Hysterotomy
Infant
Infant, Newborn
Male
Motor ability
Motor Activity - physiology
motor function
myelomeningocele
myeloschisis
neural tube defect
Plantar flexion
Pregnancy
Prenatal development
Retrospective Studies
Risk Factors
Spina bifida
Spina Bifida Cystica - diagnostic imaging
Spina Bifida Cystica - physiopathology
Spina Bifida Cystica - surgery
Treatment Outcome
Ultrasonic imaging
Ultrasonography, Prenatal
Ultrasound
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Summary:Objective To identify predictors for intact motor function (MF) at birth and at 12 months of life in babies with prenatally versus postnatally repaired open spina bifida (OSB). Design Retrospective cohort study. Setting Texas Children's Hospital, 2011–2018. Population Patients who underwent either prenatal or postnatal OSB repair. Methods Prenatal MF of the lower extremities was evaluated by ultrasound following a metameric distribution at the time of diagnosis (US1), 6 weeks postoperatively (or 6 weeks after initial evaluation in postnatally repaired cases) (US2) and at the last ultrasound before delivery (US3). At birth and at 12 months, MF was assessed clinically. Intact MF (S1) was defined as the observation of plantar flexion of the ankle. Results from logistic regression analysis are expressed as odds ratios (95% confidence intervals, P values). Results A total of 127 patients were included: 93 with prenatal repair (51 fetoscopic; 42 open hysterotomy repair) and 34 with postnatal repair. In the prenatal repair group, predictors for intact MF at birth and at 12 months included: absence of clubfeet (OR 11.3, 95% CI 3.2–39.1, P 
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.16538