Relevance of sentinel lymph node biopsy for thick melanoma in the era of immunotherapy

Sentinel lymph node biopsy provides prognostic information in patients with thick melanoma but is often underutilized. We examine regional lymph node evaluation (RLNE) in patients with thick melanoma and the effect on treatment and overall survival (OS). Patients with clinical T4N0M0 melanoma were s...

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Bibliographic Details
Published in:Surgical oncology 2020-12, Vol.35, p.309-314
Main Authors: Picado, Omar, Ryon, Emily L., Möller, Mecker G., Goel, Neha, Kesmodel, Susan B.
Format: Article
Language:English
Subjects:
Age
Biopsy
Cancer therapies
Clinical trials
Comorbidity
Data dictionaries
Hispanic people
Immunotherapy
Lymph node evaluation
Lymph nodes
Lymphatic system
Medical prognosis
Melanoma
National Cancer Database
Patients
Regression analysis
Software
Surgery
Survival
Survival analysis
Thick melanoma
Tumors
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Summary:Sentinel lymph node biopsy provides prognostic information in patients with thick melanoma but is often underutilized. We examine regional lymph node evaluation (RLNE) in patients with thick melanoma and the effect on treatment and overall survival (OS). Patients with clinical T4N0M0 melanoma were selected from the National Cancer Database (2004–2015). Binary logistic regression analysis was used to identify factors associated with RLNE and treatment. Overall survival analysis was performed. A total of 14 286 patients with clinical T4N0M0 melanoma were identified; RLNE was performed in 70.2% of patients, and positive LNs were identified in 27.1%. RLNE was more likely in males (OR:1.44, 95%CI: 1.32–1.56, p 
ISSN:0960-7404
1879-3320
DOI:10.1016/j.suronc.2020.08.032