Impact of pneumococcal conjugate vaccine on pneumonia hospitalization and mortality in children and elderly in Ecuador: Time series analyses

Highlights•Pneumococcal conjugate vaccines (PCVs) have been widely introduced recently. •Scarce evidence on the effect of PCVs on pneumonia mortality is available. •Significant impact of PCV in pneumonia hospitalization and mortality in children. •This is the first study to report PCV impact on pneu...

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Bibliographic Details
Published in:Vaccine 2020-10, Vol.38 (45), p.7033-7039
Main Authors: Jimbo Sotomayor, Ruth, Toscano, Cristiana M, Sánchez Choez, Xavier, Vilema Ortíz, Martín, Rivas Condo, Jackson, Ghisays, Gladys, Haneuse, Sebastien, Weinberger, Daniel M, McGee, Glen, de Oliveira, Lucia H
Format: Article
Language:English
Subjects:
Adults
Age groups
Aged
Allergy and Immunology
Bronchitis
Child
Child mortality
Child, Preschool
Children
Conjugates
Ear diseases
Ecuador - epidemiology
Hospitalization
Humans
Immunization
Immunization programs
Impact
Infant
Information systems
Meningitis
Middle Aged
Morbidity
Mortality
Older people
Pneumococcal conjugate vaccines
Pneumococcal diseases
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines
Pneumonia
Pneumonia - epidemiology
Pneumonia - prevention & control
Pneumonia, Pneumococcal - epidemiology
Pneumonia, Pneumococcal - prevention & control
Public health
Reduction
Regression analysis
Regression models
Serotypes
Streptococcus infections
Time series
Time series analyses
Trends
Vaccines
Vaccines, Conjugate
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Description
Summary:Highlights•Pneumococcal conjugate vaccines (PCVs) have been widely introduced recently. •Scarce evidence on the effect of PCVs on pneumonia mortality is available. •Significant impact of PCV in pneumonia hospitalization and mortality in children. •This is the first study to report PCV impact on pneumonia mortality in older adults. •Significant indirect effects of PCV vaccination in children demonstrated in adults.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2020.09.032