Influence of BDNF and MTHFR polymorphisms on hippocampal volume in first-episode psychosis

The BDNF and MTHFR genes are independently linked to the pathogenesis of schizophrenia and its neuroimaging correlates. The aim of this study was to explore, for the first time, the individual and interactional effects of the Val66Met and C677T polymorphisms on hippocampal atrophy in first-episode p...

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Bibliographic Details
Published in:Schizophrenia research 2020-09, Vol.223, p.345-352
Main Authors: Pujol, Nuria, Mané, Anna, Bergé, Daniel, Mezquida, Gisela, Amoretti, Silvia, Pérez, Lucía, González-Pinto, Ana, Barcones, Fe, Cuesta, Manuel J., Sánchez-Tomico, Georgina, Vieta, Eduard, Castro-Fornieles, Josefina, Bernardo, Miquel, Parellada, Mara
Format: Article
Language:English
Subjects:
BDNF Val66Met polymorphism
Brain-Derived Neurotrophic Factor - genetics
Case-Control Studies
First-episode psychosis
Genotype
Hippocampus
Hippocampus - diagnostic imaging
Humans
Magnetic Resonance Imaging
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
MTHFR C677T polymorphism
Polymorphism, Single Nucleotide - genetics
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - genetics
Schizophrenia - diagnostic imaging
Schizophrenia - genetics
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Summary:The BDNF and MTHFR genes are independently linked to the pathogenesis of schizophrenia and its neuroimaging correlates. The aim of this study was to explore, for the first time, the individual and interactional effects of the Val66Met and C677T polymorphisms on hippocampal atrophy in first-episode psychosis (FEP). Multi-site case-control study based on clinical, genetic (rs 6265, rs 1801133) and structural magnetic resonance imaging data from 98 non-affective FEP patients and 117 matched healthy controls (HC). Hippocampal volume was estimated using FreeSurfer software and this volume was compared between diagnostic (FEP vs HC) and genotype (Val66Met, C677T) groups. The BDNF Val66Met x MTHFR C677T effect on hippocampal volume was further evaluated through stratified analyses. After applying Bonferroni correction, diagnosis showed a significant effect for adjusted left and right hippocampal volume (FEP 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2020.08.002