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Electroactive material-based biosensors for detection and drug delivery

Electroactive materials are employed at the interface of biology and electronics due to their advantageous intrinsic properties as soft organic electronics. We examine the most recent literature of electroactive material-based biosensors and their emerging role as theranostic devices for the deliver...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2021-03, Vol.170, p.396-424
Main Authors: Olvera, Dinorath, Monaghan, Michael G.
Format: Article
Language:English
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Summary:Electroactive materials are employed at the interface of biology and electronics due to their advantageous intrinsic properties as soft organic electronics. We examine the most recent literature of electroactive material-based biosensors and their emerging role as theranostic devices for the delivery of therapeutic agents. We consider electroactive materials through the lens of smart drug delivery systems as materials that enable the release of therapeutic cargo in response to specific physiological and external stimuli and discuss the way these mechanisms are integrated into medical devices with examples of the latest advances. Studies that harness features unique to conductive polymers are emphasized; lastly, we highlight new perspectives and future research direction for this emerging technology and the challenges that remain to overcome. [Display omitted] •Electroactive materials are used in applications at the interface of biology and electronics.•Electroactive materials can facilitate active and controlled drug delivery on demand, responding within biological conditions.•Biometrics and direct drug administration can be facilitated by self-regulated biosensors.•Implantable systems still require assurance in conductivity, biocompatibility, reservoir capacity and biodegradability.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2020.09.011