Lower Cerebrovascular Reactivity Contributed to White Matter Hyperintensity‐Related Cognitive Impairment: A Resting‐State Functional MRI Study

Background Impaired cerebrovascular reactivity (CVR) plays an important role in the pathophysiology of white matter hyperintensities (WMHs). The pathogenesis of CVR in the development of WMH‐related cognitive impairment (CI) remains poorly understood. Purpose To detect the CVR status in WMH subjects...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2021-03, Vol.53 (3), p.703-711
Main Authors: Ni, Ling, Zhang, Bing, Yang, Dan, Qin, Ruomeng, Xu, Hengheng, Ma, Junyi, Shao, Pengfei, Xu, Yun
Format: Article
Language:English
Subjects:
BOLD
Brain - diagnostic imaging
cerebrovascular reactivity
Cognition
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
cognitive impairment
Confidence intervals
Correlation analysis
Data processing
Executive function
Field strength
Functional magnetic resonance imaging
Hemispheric laterality
Humans
Impairment
Information processing
Magnetic Resonance Imaging
Oxygenation
Pathogenesis
Prospective Studies
Reactivity
resting‐state
Statistical analysis
Statistical tests
Substantia alba
White Matter - diagnostic imaging
white matter hyperintensities
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Summary:Background Impaired cerebrovascular reactivity (CVR) plays an important role in the pathophysiology of white matter hyperintensities (WMHs). The pathogenesis of CVR in the development of WMH‐related cognitive impairment (CI) remains poorly understood. Purpose To detect the CVR status in WMH subjects with/without CI by using a resting‐state blood oxygenation level‐dependent (BOLD) approach and to explore the mediating relationships among CVR, WMH, and cognitive level. Study Type Prospective. Subjects Subjects with moderate to severe WMH (with CI [WMH‐CI], n = 68; without CI [WMH‐no‐CI, n = 63) as well as normal controls (NCs, n = 87). Field Strength/Sequence 3.0T with gradient‐recalled echoplanar imaging and 3D fluid‐attenuated inversion recovery. Assessment The CVR, WMH volume, and cognitive level were assessed. The CVR map was derived using BOLD signal obtained from resting‐state functional MRI data. Statistical Tests CVR maps were compared among the three groups. Partial correlation analyses were performed to correlate impaired CVR with WMH volume and cognitive test scores. Mediation analysis was conducted to determine whether WMH acted as a mediating factor between CVR and cognitive function. Results Compared with the NC group, both WMH groups showed reduced CVR in the left hemisphere (P
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.27376