Liver enhancement during hepatobiliary phase after Gd-BOPTA administration: correlation with liver and renal function

Objectives To assess the influence of liver and renal function on liver relative enhancement during hepatobiliary phase MRI after Gd-BOPTA administration. Methods In this IRB-approved retrospective cohort study, we included 326 patients who underwent Gd-BOPTA-enhanced 1.5T liver MRI, including hepat...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2021-04, Vol.31 (4), p.2490-2496
Main Authors: Bonatti, Matteo, Valletta, Riccardo, Avesani, Giacomo, Lombardo, Fabio, Cannone, Federico, Zamboni, Giulia A., Mansueto, Giancarlo, Manfredi, Riccardo, Ferro, Federica
Format: Article
Language:English
Subjects:
Bilirubin
Contrast Media
Correlation
Delay
Diagnostic Radiology
Drug dosages
Epidermal growth factor receptors
Gadolinium
Gadolinium DTPA
Hepatobiliary-Pancreas
Humans
Image Enhancement
Imaging
Injection
Internal Medicine
Interventional Radiology
Liver
Liver - diagnostic imaging
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Meglumine - analogs & derivatives
Muscles
Neuroradiology
Organometallic Compounds
Radiology
Renal function
Retrospective Studies
Statistical analysis
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To assess the influence of liver and renal function on liver relative enhancement during hepatobiliary phase MRI after Gd-BOPTA administration. Methods In this IRB-approved retrospective cohort study, we included 326 patients who underwent Gd-BOPTA-enhanced 1.5T liver MRI, including hepatobiliary phase (HBP) acquired 90–150 min after injection, in two centres between Jan 2016 and Dec 2019. Liver signal intensity was measured on native and HBP phases and normalized to paraspinal muscles. Liver normalized relative enhancement (NRE) in HBP was calculated and compared with eGFR, total serum bilirubin and HBP acquisition delay by means of Spearman r correlation test and Mann-Whitney U test. Results 221/326 patients received 0.05 mmol/Kg Gd-BOPTA (group A), whereas 105/326 received 0.1 mmol/Kg (group B). Liver NRE in HBP was significantly higher in group B than in group A (0.55vs.0.33, p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-020-07279-6