Exclusive human milk diet reduces incidence of severe intraventricular hemorrhage in extremely low birth weight infants

Objective Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)—mother’s own and/or pasteurized donor h...

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Bibliographic Details
Published in:Journal of perinatology 2021-03, Vol.41 (3), p.535-543
Main Authors: Carome, Katherine, Rahman, Amanda, Parvez, Boriana
Format: Article
Language:English
Subjects:
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Baby foods
Birth weight
Breast milk
Colostrum
Demographics
Demography
Diet
Diet therapy
Food and nutrition
Gestational age
Health aspects
Hemorrhage
Infants
Infants (Premature)
Intraventricular hemorrhage
Low-birth-weight
Medicine
Medicine & Public Health
Milk
Neuroprotection
Pasteurization
Pediatric research
Pediatric Surgery
Pediatrics
Periventricular leukomalacia
Prevention
Risk factors
Steroid hormones
Steroids
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Summary:Objective Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)—mother’s own and/or pasteurized donor human milk, human milk-derived fortifier, and oral care with colostrum/human milk vs. (2) non-EHM—bovine formula or mother’s own milk with bovine-derived fortifier. Study design Retrospective observational study of two groups of ELBW infants based on diet until 34 weeks CGA. Result There were n  = 306 infants, 127 EHM and 179 non-EHM. Demographics and morbidities were similar except higher antenatal steroids and NEC in EHM group. The rate of severe IVH/PVL was lower in EHM compared to non-EHM group (7 vs. 18%, p  
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-00834-5