Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 leve...

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Bibliographic Details
Published in:Nutrition reviews 2021-04, Vol.79 (5), p.518-528
Main Authors: Mardali, Farzaneh, Fatahi, Somaye, Alinaghizadeh, Maryam, Kord Varkaneh, Hamed, Sohouli, Mohammad Hassan, Shidfar, Farzad, Găman, Mihnea-Alexandru
Format: Article
Language:English
Subjects:
Adult
Female
Folic Acid
Homocysteine
Humans
Observational Studies as Topic
Pre-Eclampsia - blood
Pregnancy
Vitamin B 12 - blood
Young Adult
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Summary:Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P 
ISSN:0029-6643
1753-4887
DOI:10.1093/nutrit/nuaa096