The association between IL-1 family gene polymorphisms and colorectal cancer: A meta-analysis

• Published in: Gene 2021-02, Vol.769, p.145187-145187, Article 145187
• Main Authors: Liu, Li, Zhai, Zhenglong, Wang, Danyang, Ding, Yun, Chen, Xiaoqing, Wang, Qiqi, Shu, Zheyue, Wu, Minglan, Chen, Lei, He, Xuelin, Fan, Dazhi, Pan, Faming, Xing, Meiyuan
• Format: Article
• Language: English
• Subjects: Colorectal cancer; Colorectal Neoplasms - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; IL-1RN; IL-1α; IL-1β; Interleukin-1 - genetics; Polymorphism; Polymorphism, Genetic; Publication Bias
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2020.145187

•Associations between IL-1 family gene polymorphisms and risk of CRC were studied.•IL-1a 3783553, IL-1β+31 C/T, +51C/T and IL-1RN RNVR are critical genes for CRC.•IL-1B +511 C/T and IL-1RN+ 2018T/C were associated with CRC in Asian.•More evidences were provided for the role of IL-1faminly gene polymorphisms on CRC. Colorectal cancer (CRC) is a major public health problem given its high incidence and mortality. This study focuses on examining the associations between IL-1α, IL-1β, and IL-1RN polymorphisms and colorectal cancer susceptibility. A systematic literature search of PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure) and Wan Fang databases was conducted to identify relevant studies. Relevant data were extracted from the original included studies. The correlation was demonstrated based on the odds ratio (OR) and corresponding 95% confidence intervals (95% CIs). Publication bias was investigated by Egger's line regression test and Begg's funnel plot. Eighteen independent studies involving 6218 cases and 10160 controls were eligible for this pooled analysis. Overall, the result revealed that the IL-1α rs3783553 polymorphism was significantly associated with an increased risk of CRC (G vs. C, OR = 1.02, 95% CI = 0.90–1.15, I2 = 51%, P = 0.78; GG vs. CC, OR = 1.97, 95% CI = 1.04–3.74, I2 = 70%, P = 0.04; GC vs. CC, OR = 1.75, 95% CI = 1.12–2.75, I2 = 42%, P = 0.01; GG + GC vs. CC, OR = 1.85, 95% CI = 1.08–3.18, I2 = 63%, P = 0.03; and GG vs. GC + CC, OR = 1.28, 95% CI = 1.04–1.58, I2 = 39%, P = 0.02), and significance was also noted for IL-1RN VNTR under the dominant model (22 + 2L vs. LL, OR = 1.49, 95% CI = 1.01–2.19, I2 = 77%, P = 0.045) and allelic contrast model (2 vs. L, OR = 1.28, 95% CI = 1.00–1.64, I2 = 58.6%, P = 0.047). For IL-1β + 31C/T, significance was observed in the dominant model (CC + CT vs. TT, OR = 0.83, 95% CI = 0.69–0.99, I2 = 52%, P = 0.034) and the heterozygous model (CT vs. TT, OR = 0.80, 95% CI = 0.65–0.98, I2 = 60%, P = 0.04). For IL-1β + 511 C/T, a significant association was noted in four gene models (CT vs. TT, OR = 0.72, 95% CI = 0.63–0.83, I2 = 0%, P