Periodontitis and risk of prevalent and incident coronary heart disease events

Objective To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland. Methods A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and in...

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Bibliographic Details
Published in:Journal of clinical periodontology 2020-12, Vol.47 (12), p.1446-1456
Main Authors: Winning, Lewis, Patterson, Christopher C., Linden, Katie, Evans, Alun, Yarnel, John, McKeown, Pascal P., Kee, Frank, Linden, Gerard J.
Format: Article
Language:English
Subjects:
Cardiovascular disease
Coronary artery disease
Coronary Disease - epidemiology
coronary heart disease
Cross-Sectional Studies
Dentistry
Gum disease
Heart diseases
Humans
Incidence
inflammation
Male
Middle Aged
Northern Ireland - epidemiology
Periodontitis
Periodontitis - epidemiology
Proportional Hazards Models
Risk Factors
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Summary:Objective To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland. Methods A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross‐sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD. Results The mean age of the men at baseline was 63.7 (SD 3.0) years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15–4.02), p = 0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow‐up of 12.7 years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81–2.29), p = 0.24. Conclusions In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.13377