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Periodontitis and risk of prevalent and incident coronary heart disease events
Objective To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland. Methods A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and in...
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| Published in: | Journal of clinical periodontology 2020-12, Vol.47 (12), p.1446-1456 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c3937-947ebcb8ecb49f37118b6bd488166f076a8ce16efa00b9c072e19e1c8f3874243 |
| container_end_page | 1456 |
| container_issue | 12 |
| container_start_page | 1446 |
| container_title | Journal of clinical periodontology |
| container_volume | 47 |
| creator | Winning, Lewis Patterson, Christopher C. Linden, Katie Evans, Alun Yarnel, John McKeown, Pascal P. Kee, Frank Linden, Gerard J. |
| description | Objective
To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland.
Methods
A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross‐sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD.
Results
The mean age of the men at baseline was 63.7 (SD 3.0) years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15–4.02), p = 0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow‐up of 12.7 years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81–2.29), p = 0.24.
Conclusions
In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD. |
| doi_str_mv | 10.1111/jcpe.13377 |
| format | article |
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To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland.
Methods
A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross‐sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD.
Results
The mean age of the men at baseline was 63.7 (SD 3.0) years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15–4.02), p = 0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow‐up of 12.7 years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81–2.29), p = 0.24.
Conclusions
In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13377</identifier><identifier>PMID: 32998173</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Cardiovascular disease ; Coronary artery disease ; Coronary Disease - epidemiology ; coronary heart disease ; Cross-Sectional Studies ; Dentistry ; Gum disease ; Heart diseases ; Humans ; Incidence ; inflammation ; Male ; Middle Aged ; Northern Ireland - epidemiology ; Periodontitis ; Periodontitis - epidemiology ; Proportional Hazards Models ; Risk Factors</subject><ispartof>Journal of clinical periodontology, 2020-12, Vol.47 (12), p.1446-1456</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd</rights><rights>2020 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-947ebcb8ecb49f37118b6bd488166f076a8ce16efa00b9c072e19e1c8f3874243</citedby><cites>FETCH-LOGICAL-c3937-947ebcb8ecb49f37118b6bd488166f076a8ce16efa00b9c072e19e1c8f3874243</cites><orcidid>0000-0002-8783-8089</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32998173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winning, Lewis</creatorcontrib><creatorcontrib>Patterson, Christopher C.</creatorcontrib><creatorcontrib>Linden, Katie</creatorcontrib><creatorcontrib>Evans, Alun</creatorcontrib><creatorcontrib>Yarnel, John</creatorcontrib><creatorcontrib>McKeown, Pascal P.</creatorcontrib><creatorcontrib>Kee, Frank</creatorcontrib><creatorcontrib>Linden, Gerard J.</creatorcontrib><title>Periodontitis and risk of prevalent and incident coronary heart disease events</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Objective
To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland.
Methods
A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross‐sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD.
Results
The mean age of the men at baseline was 63.7 (SD 3.0) years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15–4.02), p = 0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow‐up of 12.7 years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81–2.29), p = 0.24.
Conclusions
In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.</description><subject>Cardiovascular disease</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - epidemiology</subject><subject>coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Gum disease</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>inflammation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Northern Ireland - epidemiology</subject><subject>Periodontitis</subject><subject>Periodontitis - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kE1LAzEQhoMotlYv_gBZ8CLC1mQT83GUUr8o2oOCtyWbncXU7aYmu5X-e9MPPXhwLsPMPLzM-yJ0SvCQxLqamQUMCaVC7KE-4Rin-Jq87aM-ppimXAnVQ0chzDAmglJ6iHo0U0rGoY-epuCtK13T2taGRDdl4m34SFyVLDwsdQ1Nu9naxthyPRjnXaP9KnkH7duktAF0gASW8RiO0UGl6wAnuz5Ar7fjl9F9Onm-exjdTFJDFRWpYgIKU0gwBVMVFYTIghclk5JwXmHBtTRAOFQa40IZLDIgCoiRFZWCZYwO0MVWd-HdZwehzec2GKhr3YDrQp4xJiTL1oYH6PwPOnOdb-J3keKMcSIzEqnLLWW8C8FDlS-8nUebOcH5OuV8nXK-STnCZzvJrphD-Yv-xBoBsgW-bA2rf6Tyx9F0vBX9BpNJhvo</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Winning, Lewis</creator><creator>Patterson, Christopher C.</creator><creator>Linden, Katie</creator><creator>Evans, Alun</creator><creator>Yarnel, John</creator><creator>McKeown, Pascal P.</creator><creator>Kee, Frank</creator><creator>Linden, Gerard J.</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8783-8089</orcidid></search><sort><creationdate>202012</creationdate><title>Periodontitis and risk of prevalent and incident coronary heart disease events</title><author>Winning, Lewis ; Patterson, Christopher C. ; Linden, Katie ; Evans, Alun ; Yarnel, John ; McKeown, Pascal P. ; Kee, Frank ; Linden, Gerard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-947ebcb8ecb49f37118b6bd488166f076a8ce16efa00b9c072e19e1c8f3874243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cardiovascular disease</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - epidemiology</topic><topic>coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Gum disease</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>inflammation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Northern Ireland - epidemiology</topic><topic>Periodontitis</topic><topic>Periodontitis - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winning, Lewis</creatorcontrib><creatorcontrib>Patterson, Christopher C.</creatorcontrib><creatorcontrib>Linden, Katie</creatorcontrib><creatorcontrib>Evans, Alun</creatorcontrib><creatorcontrib>Yarnel, John</creatorcontrib><creatorcontrib>McKeown, Pascal P.</creatorcontrib><creatorcontrib>Kee, Frank</creatorcontrib><creatorcontrib>Linden, Gerard J.</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winning, Lewis</au><au>Patterson, Christopher C.</au><au>Linden, Katie</au><au>Evans, Alun</au><au>Yarnel, John</au><au>McKeown, Pascal P.</au><au>Kee, Frank</au><au>Linden, Gerard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontitis and risk of prevalent and incident coronary heart disease events</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>47</volume><issue>12</issue><spage>1446</spage><epage>1456</epage><pages>1446-1456</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Objective
To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle‐aged men from Northern Ireland.
Methods
A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross‐sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD.
Results
The mean age of the men at baseline was 63.7 (SD 3.0) years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15–4.02), p = 0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow‐up of 12.7 years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81–2.29), p = 0.24.
Conclusions
In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>32998173</pmid><doi>10.1111/jcpe.13377</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8783-8089</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6979 |
| ispartof | Journal of clinical periodontology, 2020-12, Vol.47 (12), p.1446-1456 |
| issn | 0303-6979 1600-051X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2447842017 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Cardiovascular disease Coronary artery disease Coronary Disease - epidemiology coronary heart disease Cross-Sectional Studies Dentistry Gum disease Heart diseases Humans Incidence inflammation Male Middle Aged Northern Ireland - epidemiology Periodontitis Periodontitis - epidemiology Proportional Hazards Models Risk Factors |
| title | Periodontitis and risk of prevalent and incident coronary heart disease events |
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