Histological and cellular evaluation of anterior cruciate ligament

We hypothesized that the torn anterior cruciate ligament (ACL) demonstrates a great healing response after initial trauma and has competent cells leading to the healing but differs in its response based on the type of tear and duration of injury. This study aimed to evaluate the histological and cel...

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Bibliographic Details
Published in:The knee 2020-10, Vol.27 (5), p.1510-1518
Main Authors: Butt, Umer, Khan, Zainab Aqeel, Zahir, Naila, Khan, Zeeshan, Vuletic, Filip, Shah, Imran, Shah, Junaid Ali, Siddiqui, Athar Muniruddin, Hudetz, Damir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Angiogenesis
Anterior cruciate ligament
Anterior cruciate ligament (ACL)
Anterior Cruciate Ligament - blood supply
Anterior Cruciate Ligament - pathology
Anterior Cruciate Ligament Injuries - pathology
Arthroscopy
Biopsy
Cartilage
CD34 antigen
Cell Proliferation
Endothelial cells
Female
Fibroblasts - pathology
Fibrocytes
Histology
Humans
Injuries
Knee
Ligaments
Male
Middle Aged
Neovascularization, Physiologic
Prospective Studies
Stump preserving reconstruction
Trauma
Variance analysis
Young Adult
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Summary:We hypothesized that the torn anterior cruciate ligament (ACL) demonstrates a great healing response after initial trauma and has competent cells leading to the healing but differs in its response based on the type of tear and duration of injury. This study aimed to evaluate the histological and cellular responses to the injured ACL. Fifty-two tissue samples from the ACL were harvested from patients undergoing arthroscopy. Detailed histological and cellular examinations were performed for ligament angiogenesis, fibrocytes, and synovial tissue infiltration. We compared the cellular response to injury in partially and completely ruptured ACLs. The duration of ACL injury and its response to cellular characteristics were also examined. Immunohistochemical studies using cluster of differentiation 34 (CD34) staining was used to evaluate endothelial cells and fibrocytes. We found a significantly higher density of synovial and ligament angiogenesis and fibrocytes at the torn end of ACL (Mann–Whitney, P 
ISSN:0968-0160
1873-5800
DOI:10.1016/j.knee.2020.08.002