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Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice

Purpose Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a...

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Bibliographic Details
Published in:European journal of nutrition 2021-06, Vol.60 (4), p.2029-2045
Main Authors: Hou, Dianzhi, Zhao, Qingyu, Yousaf, Laraib, Xue, Yong, Shen, Qun
Format: Article
Language:English
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Summary:Purpose Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD. Methods Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice. Results MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations ( P  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-020-02395-x