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Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice
Purpose Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a...
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| Published in: | European journal of nutrition 2021-06, Vol.60 (4), p.2029-2045 |
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| Main Authors: | , , , , |
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| container_end_page | 2045 |
| container_issue | 4 |
| container_start_page | 2029 |
| container_title | European journal of nutrition |
| container_volume | 60 |
| creator | Hou, Dianzhi Zhao, Qingyu Yousaf, Laraib Xue, Yong Shen, Qun |
| description | Purpose
Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD.
Methods
Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice.
Results
MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations (
P
|
| doi_str_mv | 10.1007/s00394-020-02395-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2448411217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2529604977</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a68e51d309aef468b3fed9c13e4e4cd3e0db4be25e0097d91925203d3f575d573</originalsourceid><addsrcrecordid>eNp9kc9u3CAQxlGVqvnTvkAPFVIuuTgdDNjLsY3SJlKkXtozwjDsEtmwNbhKHiFvHTabpFIPPSAYze_7ZtBHyEcG5wyg_5wBuBINtFAPV7K5e0OOmOBd07VMHry-oT8kxznfAlSsY-_IIecAUq3giDx8xYg-2GBGit6jLZkmT6clrumAJtKM6KhNptAUadkg3c74B2MJtazgJqw3ja9dF7A0IbrFVj4NmEO5pya6J82U3DKaF816KXQKdk5DSMXQEHcVvidvvRkzfni-T8ivb5c_L66amx_fry--3DSW97I0pluhZI6DMuhFtxq4R6cs4yhQWMcR3CAGbCUCqN4pplrZAnfcy1462fMTcrb33c7p94K56Clki-NoIqYl61aIlWCsZTv09B_0Ni1zrNvpaqo6EKrfUe2eqj_KeUavt3OYzHyvGehdUHoflK5B6aeg9F0VfXq2XoYJ3avkJZkK8D2Qayuucf47-z-2j6L9n3s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2529604977</pqid></control><display><type>article</type><title>Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice</title><source>EBSCOhost SPORTDiscus with Full Text</source><source>Springer Link</source><creator>Hou, Dianzhi ; Zhao, Qingyu ; Yousaf, Laraib ; Xue, Yong ; Shen, Qun</creator><creatorcontrib>Hou, Dianzhi ; Zhao, Qingyu ; Yousaf, Laraib ; Xue, Yong ; Shen, Qun</creatorcontrib><description>Purpose
Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD.
Methods
Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice.
Results
MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations (
P
< 0.05), which was accompanied by improvements in hepatic steatosis and adipocyte size. Especially, the elevated fasting blood glucose and insulin resistance were also significantly improved by MBC supplementation (
P
< 0.05). Furthermore, high-throughput sequencing of the 16S rRNA gene revealed that MBC could normalize HFD-induced gut microbiota dysbiosis. MBC not only could promote the bloom of
Akkermansia
, but also restore several HFD-dependent taxa (
Blautia
,
Ruminiclostridium_9
,
Bilophila
, and
unclassified_f_Ruminococcaceae
) back to normal status, co-occurring with the decreases in obesity-related indices.
Conclusions
This study provides evidence that MBC may be mainly responsible for the beneficial effects of whole mung bean on preventing the HFD-induced changes, thus enlarging the application value of MBC.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-020-02395-x</identifier><identifier>PMID: 33005980</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adipose tissue ; Beans ; Chemistry ; Chemistry and Materials Science ; Cytokines ; Dietary supplements ; Dysbacteriosis ; Fatty liver ; High fat diet ; Inflammation ; Insulin ; Insulin resistance ; Intestinal microflora ; Lipopolysaccharides ; Microbiota ; Next-generation sequencing ; Nutrition ; Obesity ; Original Contribution ; rRNA 16S ; Seed coats ; Steatosis ; Vigna radiata</subject><ispartof>European journal of nutrition, 2021-06, Vol.60 (4), p.2029-2045</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a68e51d309aef468b3fed9c13e4e4cd3e0db4be25e0097d91925203d3f575d573</citedby><cites>FETCH-LOGICAL-c375t-a68e51d309aef468b3fed9c13e4e4cd3e0db4be25e0097d91925203d3f575d573</cites><orcidid>0000-0002-2154-6104</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33005980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Dianzhi</creatorcontrib><creatorcontrib>Zhao, Qingyu</creatorcontrib><creatorcontrib>Yousaf, Laraib</creatorcontrib><creatorcontrib>Xue, Yong</creatorcontrib><creatorcontrib>Shen, Qun</creatorcontrib><title>Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD.
Methods
Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice.
Results
MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations (
P
< 0.05), which was accompanied by improvements in hepatic steatosis and adipocyte size. Especially, the elevated fasting blood glucose and insulin resistance were also significantly improved by MBC supplementation (
P
< 0.05). Furthermore, high-throughput sequencing of the 16S rRNA gene revealed that MBC could normalize HFD-induced gut microbiota dysbiosis. MBC not only could promote the bloom of
Akkermansia
, but also restore several HFD-dependent taxa (
Blautia
,
Ruminiclostridium_9
,
Bilophila
, and
unclassified_f_Ruminococcaceae
) back to normal status, co-occurring with the decreases in obesity-related indices.
Conclusions
This study provides evidence that MBC may be mainly responsible for the beneficial effects of whole mung bean on preventing the HFD-induced changes, thus enlarging the application value of MBC.</description><subject>Adipose tissue</subject><subject>Beans</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cytokines</subject><subject>Dietary supplements</subject><subject>Dysbacteriosis</subject><subject>Fatty liver</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intestinal microflora</subject><subject>Lipopolysaccharides</subject><subject>Microbiota</subject><subject>Next-generation sequencing</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Original Contribution</subject><subject>rRNA 16S</subject><subject>Seed coats</subject><subject>Steatosis</subject><subject>Vigna radiata</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u3CAQxlGVqvnTvkAPFVIuuTgdDNjLsY3SJlKkXtozwjDsEtmwNbhKHiFvHTabpFIPPSAYze_7ZtBHyEcG5wyg_5wBuBINtFAPV7K5e0OOmOBd07VMHry-oT8kxznfAlSsY-_IIecAUq3giDx8xYg-2GBGit6jLZkmT6clrumAJtKM6KhNptAUadkg3c74B2MJtazgJqw3ja9dF7A0IbrFVj4NmEO5pya6J82U3DKaF816KXQKdk5DSMXQEHcVvidvvRkzfni-T8ivb5c_L66amx_fry--3DSW97I0pluhZI6DMuhFtxq4R6cs4yhQWMcR3CAGbCUCqN4pplrZAnfcy1462fMTcrb33c7p94K56Clki-NoIqYl61aIlWCsZTv09B_0Ni1zrNvpaqo6EKrfUe2eqj_KeUavt3OYzHyvGehdUHoflK5B6aeg9F0VfXq2XoYJ3avkJZkK8D2Qayuucf47-z-2j6L9n3s</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Hou, Dianzhi</creator><creator>Zhao, Qingyu</creator><creator>Yousaf, Laraib</creator><creator>Xue, Yong</creator><creator>Shen, Qun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2154-6104</orcidid></search><sort><creationdate>20210601</creationdate><title>Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice</title><author>Hou, Dianzhi ; Zhao, Qingyu ; Yousaf, Laraib ; Xue, Yong ; Shen, Qun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a68e51d309aef468b3fed9c13e4e4cd3e0db4be25e0097d91925203d3f575d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Beans</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cytokines</topic><topic>Dietary supplements</topic><topic>Dysbacteriosis</topic><topic>Fatty liver</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intestinal microflora</topic><topic>Lipopolysaccharides</topic><topic>Microbiota</topic><topic>Next-generation sequencing</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Original Contribution</topic><topic>rRNA 16S</topic><topic>Seed coats</topic><topic>Steatosis</topic><topic>Vigna radiata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Dianzhi</creatorcontrib><creatorcontrib>Zhao, Qingyu</creatorcontrib><creatorcontrib>Yousaf, Laraib</creatorcontrib><creatorcontrib>Xue, Yong</creatorcontrib><creatorcontrib>Shen, Qun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Career and Technical Education</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Dianzhi</au><au>Zhao, Qingyu</au><au>Yousaf, Laraib</au><au>Xue, Yong</au><au>Shen, Qun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>60</volume><issue>4</issue><spage>2029</spage><epage>2045</epage><pages>2029-2045</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD.
Methods
Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice.
Results
MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations (
P
< 0.05), which was accompanied by improvements in hepatic steatosis and adipocyte size. Especially, the elevated fasting blood glucose and insulin resistance were also significantly improved by MBC supplementation (
P
< 0.05). Furthermore, high-throughput sequencing of the 16S rRNA gene revealed that MBC could normalize HFD-induced gut microbiota dysbiosis. MBC not only could promote the bloom of
Akkermansia
, but also restore several HFD-dependent taxa (
Blautia
,
Ruminiclostridium_9
,
Bilophila
, and
unclassified_f_Ruminococcaceae
) back to normal status, co-occurring with the decreases in obesity-related indices.
Conclusions
This study provides evidence that MBC may be mainly responsible for the beneficial effects of whole mung bean on preventing the HFD-induced changes, thus enlarging the application value of MBC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33005980</pmid><doi>10.1007/s00394-020-02395-x</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-2154-6104</orcidid></addata></record> |
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| ispartof | European journal of nutrition, 2021-06, Vol.60 (4), p.2029-2045 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2448411217 |
| source | EBSCOhost SPORTDiscus with Full Text; Springer Link |
| subjects | Adipose tissue Beans Chemistry Chemistry and Materials Science Cytokines Dietary supplements Dysbacteriosis Fatty liver High fat diet Inflammation Insulin Insulin resistance Intestinal microflora Lipopolysaccharides Microbiota Next-generation sequencing Nutrition Obesity Original Contribution rRNA 16S Seed coats Steatosis Vigna radiata |
| title | Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice |
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