Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant

[Display omitted] •Antimicrobial peptides (AMPs) are coated on biomaterials by anionic surfactant.•Two AMPs are coated simultaneously by anionic surfactants.•AMPs are coated on polystyrene, silicone, polyurethane and titanium.•AMPs coated on silicone disc could inhibit bacterial adherence.•AMPs coat...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-12, Vol.196, p.111364-111364, Article 111364
Main Authors: Wang, Shih-Han, Tang, Tony Wen-Hung, Wu, Eden, Wang, Dan-Wei, Wang, Chiu-Feng, Liao, You-Di
Format: Article
Language:English
Subjects:
Anionic surfactant
Antimicrobial peptide
Bacterial adherence
Biomaterial
Mouse
Silicone
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Summary:[Display omitted] •Antimicrobial peptides (AMPs) are coated on biomaterials by anionic surfactant.•Two AMPs are coated simultaneously by anionic surfactants.•AMPs are coated on polystyrene, silicone, polyurethane and titanium.•AMPs coated on silicone disc could inhibit bacterial adherence.•AMPs coated on silicone tubing could prevent mouse urinary tract infection. Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria that are tolerant to most antibiotics. In this report, antimicrobial peptides (AMPs) were coated onto biomaterials by the aid of surfactant through hydrophobic interactions. To increase the coating efficiency, stability of AMPs in body fluids and spectrum of antimicrobial activity, pairs of AMPs were coated simultaneously onto various substrates, such as silicone, polyurethane and titanium, which are commonly used components of biomedical devices. These coated AMPs exhibited very low cytotoxicity and hemolytic activities because they were gradually released into urine or serum. The AMP pairs, such as T9W + SAAP159 and T9W + RRIKA, coated onto the silicone discs were able to inhibit in vitro bacterial adherence in urine. Most importantly, AMP pairs coated onto the silicone tubing by surfactant SDBS could prevent bacterial adherence to mouse bladder and the silicone tubing implanted within it. These results provide a promising approach towards circumventing urinary catheter-associated infections caused by bacterial adherence.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2020.111364