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Altered brain network function during attention-modulated visual processing in multiple sclerosis
Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce. Objective: To investigate connectivity within and betwe...
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| Published in: | Multiple sclerosis 2021-08, Vol.27 (9), p.1341-1349 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c384t-488ab47469673270037396b227bdc1bd42292d5e22fe8e1d7a6c1c6ab71adf053 |
| container_end_page | 1349 |
| container_issue | 9 |
| container_start_page | 1341 |
| container_title | Multiple sclerosis |
| container_volume | 27 |
| creator | Veréb, Dániel Tóth, Eszter Bozsik, Bence Király, András Szabó, Nikoletta Kincses, Bálint Kocsis, Krisztián Faragó, Péter László, Vécsei Bencsik, Krisztina Klivényi, Péter Kincses, Zsigmond Tamás |
| description | Background:
Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce.
Objective:
To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance.
Methods:
A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery.
Results:
TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p |
| doi_str_mv | 10.1177/1352458520958360 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2448635938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1352458520958360</sage_id><sourcerecordid>2560029813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-488ab47469673270037396b227bdc1bd42292d5e22fe8e1d7a6c1c6ab71adf053</originalsourceid><addsrcrecordid>eNp1kMtLxDAQxoMouK7ePRa8eKnmnfS4LL5A8KLnkibpkjVt1zwU_3tTVhAWPM0w8_s-vhkALhG8QUiIW0QYpkwyDBsmCYdHYIGoEDVsBDwufVnX8_4UnMW4hRAKQdgCqJVPNlhTdUG5sRpt-prCe9XnUSc3jZXJwY2bSqVkx3lQD5PJXqWi-HQxK1_twqRtjDNVDIbsk9t5W0XtbZiii-fgpFc-2ovfugRv93ev68f6-eXhab16rjWRNNVUStVRQXnDBcECQiJIwzuMRWc06gzFuMGGWYx7Ky0yQnGNNFedQMr0kJEluN77lkAf2cbUDi5q670a7ZRjiymVnLCGyIJeHaDbKYexpGsx4xDiRiJSKLindLkjBtu3u-AGFb5bBNv55-3hz4uk3kui2tg_03_5H0FTgaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2560029813</pqid></control><display><type>article</type><title>Altered brain network function during attention-modulated visual processing in multiple sclerosis</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>Veréb, Dániel ; Tóth, Eszter ; Bozsik, Bence ; Király, András ; Szabó, Nikoletta ; Kincses, Bálint ; Kocsis, Krisztián ; Faragó, Péter ; László, Vécsei ; Bencsik, Krisztina ; Klivényi, Péter ; Kincses, Zsigmond Tamás</creator><creatorcontrib>Veréb, Dániel ; Tóth, Eszter ; Bozsik, Bence ; Király, András ; Szabó, Nikoletta ; Kincses, Bálint ; Kocsis, Krisztián ; Faragó, Péter ; László, Vécsei ; Bencsik, Krisztina ; Klivényi, Péter ; Kincses, Zsigmond Tamás</creatorcontrib><description><![CDATA[Background:
Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce.
Objective:
To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance.
Methods:
A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery.
Results:
TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p < 0.032, p < 0.023). Connectivity between visual/attention-related and default-mode components was higher in patients (p < 0.043), correlating with Brief Visuospatial Memory Test–Revised (BVMT-R) scores (R = −0.48, p < 0.036). Patients showed reduced connectivity between the right intraparietal sulcus (rIPS) and frontal eye field (rFEF), and bilateral frontal eye fields (p < 0.012, p < 0.003). Reduced rIPS-rFEF connectivity came with lower Symbol Digit Modalities Test (SDMT)/BVMT-R scores in patients (R = 0.53, p < 0.02, R = 0.46, p < 0.049).
Conclusion:
Attention-related networks show altered connectivity during task performance in RRMS patients, scaling with cognitive disability.]]></description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458520958360</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Attention task ; Brain mapping ; Cognitive ability ; Executive function ; Functional magnetic resonance imaging ; Information processing ; Intraparietal sulcus ; Multiple sclerosis ; Neural networks ; Neuroimaging ; Receptive field ; Spatial memory ; Visual perception</subject><ispartof>Multiple sclerosis, 2021-08, Vol.27 (9), p.1341-1349</ispartof><rights>The Author(s), 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-488ab47469673270037396b227bdc1bd42292d5e22fe8e1d7a6c1c6ab71adf053</citedby><cites>FETCH-LOGICAL-c384t-488ab47469673270037396b227bdc1bd42292d5e22fe8e1d7a6c1c6ab71adf053</cites><orcidid>0000-0002-1442-4475 ; 0000-0003-2077-5252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Veréb, Dániel</creatorcontrib><creatorcontrib>Tóth, Eszter</creatorcontrib><creatorcontrib>Bozsik, Bence</creatorcontrib><creatorcontrib>Király, András</creatorcontrib><creatorcontrib>Szabó, Nikoletta</creatorcontrib><creatorcontrib>Kincses, Bálint</creatorcontrib><creatorcontrib>Kocsis, Krisztián</creatorcontrib><creatorcontrib>Faragó, Péter</creatorcontrib><creatorcontrib>László, Vécsei</creatorcontrib><creatorcontrib>Bencsik, Krisztina</creatorcontrib><creatorcontrib>Klivényi, Péter</creatorcontrib><creatorcontrib>Kincses, Zsigmond Tamás</creatorcontrib><title>Altered brain network function during attention-modulated visual processing in multiple sclerosis</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description><![CDATA[Background:
Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce.
Objective:
To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance.
Methods:
A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery.
Results:
TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p < 0.032, p < 0.023). Connectivity between visual/attention-related and default-mode components was higher in patients (p < 0.043), correlating with Brief Visuospatial Memory Test–Revised (BVMT-R) scores (R = −0.48, p < 0.036). Patients showed reduced connectivity between the right intraparietal sulcus (rIPS) and frontal eye field (rFEF), and bilateral frontal eye fields (p < 0.012, p < 0.003). Reduced rIPS-rFEF connectivity came with lower Symbol Digit Modalities Test (SDMT)/BVMT-R scores in patients (R = 0.53, p < 0.02, R = 0.46, p < 0.049).
Conclusion:
Attention-related networks show altered connectivity during task performance in RRMS patients, scaling with cognitive disability.]]></description><subject>Attention task</subject><subject>Brain mapping</subject><subject>Cognitive ability</subject><subject>Executive function</subject><subject>Functional magnetic resonance imaging</subject><subject>Information processing</subject><subject>Intraparietal sulcus</subject><subject>Multiple sclerosis</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Receptive field</subject><subject>Spatial memory</subject><subject>Visual perception</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtLxDAQxoMouK7ePRa8eKnmnfS4LL5A8KLnkibpkjVt1zwU_3tTVhAWPM0w8_s-vhkALhG8QUiIW0QYpkwyDBsmCYdHYIGoEDVsBDwufVnX8_4UnMW4hRAKQdgCqJVPNlhTdUG5sRpt-prCe9XnUSc3jZXJwY2bSqVkx3lQD5PJXqWi-HQxK1_twqRtjDNVDIbsk9t5W0XtbZiii-fgpFc-2ovfugRv93ev68f6-eXhab16rjWRNNVUStVRQXnDBcECQiJIwzuMRWc06gzFuMGGWYx7Ky0yQnGNNFedQMr0kJEluN77lkAf2cbUDi5q670a7ZRjiymVnLCGyIJeHaDbKYexpGsx4xDiRiJSKLindLkjBtu3u-AGFb5bBNv55-3hz4uk3kui2tg_03_5H0FTgaA</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Veréb, Dániel</creator><creator>Tóth, Eszter</creator><creator>Bozsik, Bence</creator><creator>Király, András</creator><creator>Szabó, Nikoletta</creator><creator>Kincses, Bálint</creator><creator>Kocsis, Krisztián</creator><creator>Faragó, Péter</creator><creator>László, Vécsei</creator><creator>Bencsik, Krisztina</creator><creator>Klivényi, Péter</creator><creator>Kincses, Zsigmond Tamás</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1442-4475</orcidid><orcidid>https://orcid.org/0000-0003-2077-5252</orcidid></search><sort><creationdate>202108</creationdate><title>Altered brain network function during attention-modulated visual processing in multiple sclerosis</title><author>Veréb, Dániel ; Tóth, Eszter ; Bozsik, Bence ; Király, András ; Szabó, Nikoletta ; Kincses, Bálint ; Kocsis, Krisztián ; Faragó, Péter ; László, Vécsei ; Bencsik, Krisztina ; Klivényi, Péter ; Kincses, Zsigmond Tamás</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-488ab47469673270037396b227bdc1bd42292d5e22fe8e1d7a6c1c6ab71adf053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Attention task</topic><topic>Brain mapping</topic><topic>Cognitive ability</topic><topic>Executive function</topic><topic>Functional magnetic resonance imaging</topic><topic>Information processing</topic><topic>Intraparietal sulcus</topic><topic>Multiple sclerosis</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Receptive field</topic><topic>Spatial memory</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veréb, Dániel</creatorcontrib><creatorcontrib>Tóth, Eszter</creatorcontrib><creatorcontrib>Bozsik, Bence</creatorcontrib><creatorcontrib>Király, András</creatorcontrib><creatorcontrib>Szabó, Nikoletta</creatorcontrib><creatorcontrib>Kincses, Bálint</creatorcontrib><creatorcontrib>Kocsis, Krisztián</creatorcontrib><creatorcontrib>Faragó, Péter</creatorcontrib><creatorcontrib>László, Vécsei</creatorcontrib><creatorcontrib>Bencsik, Krisztina</creatorcontrib><creatorcontrib>Klivényi, Péter</creatorcontrib><creatorcontrib>Kincses, Zsigmond Tamás</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veréb, Dániel</au><au>Tóth, Eszter</au><au>Bozsik, Bence</au><au>Király, András</au><au>Szabó, Nikoletta</au><au>Kincses, Bálint</au><au>Kocsis, Krisztián</au><au>Faragó, Péter</au><au>László, Vécsei</au><au>Bencsik, Krisztina</au><au>Klivényi, Péter</au><au>Kincses, Zsigmond Tamás</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered brain network function during attention-modulated visual processing in multiple sclerosis</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2021-08</date><risdate>2021</risdate><volume>27</volume><issue>9</issue><spage>1341</spage><epage>1349</epage><pages>1341-1349</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><abstract><![CDATA[Background:
Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce.
Objective:
To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance.
Methods:
A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery.
Results:
TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p < 0.032, p < 0.023). Connectivity between visual/attention-related and default-mode components was higher in patients (p < 0.043), correlating with Brief Visuospatial Memory Test–Revised (BVMT-R) scores (R = −0.48, p < 0.036). Patients showed reduced connectivity between the right intraparietal sulcus (rIPS) and frontal eye field (rFEF), and bilateral frontal eye fields (p < 0.012, p < 0.003). Reduced rIPS-rFEF connectivity came with lower Symbol Digit Modalities Test (SDMT)/BVMT-R scores in patients (R = 0.53, p < 0.02, R = 0.46, p < 0.049).
Conclusion:
Attention-related networks show altered connectivity during task performance in RRMS patients, scaling with cognitive disability.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/1352458520958360</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1442-4475</orcidid><orcidid>https://orcid.org/0000-0003-2077-5252</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Multiple sclerosis, 2021-08, Vol.27 (9), p.1341-1349 |
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| language | eng |
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| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Attention task Brain mapping Cognitive ability Executive function Functional magnetic resonance imaging Information processing Intraparietal sulcus Multiple sclerosis Neural networks Neuroimaging Receptive field Spatial memory Visual perception |
| title | Altered brain network function during attention-modulated visual processing in multiple sclerosis |
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