SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins

This study provides supporting evidence for the association between SOX9 and liquid–liquid phase separation. We show that SOX9 colocalized with a paraspeckle protein NONO in many, but not all, of the immortalized and primary murine Sertoli cells examined. In addition, we confirmed that SOX9 has stru...

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Bibliographic Details
Published in:Molecular reproduction and development 2020-11, Vol.87 (11), p.1124-1125
Main Authors: Akiba, Kazuhisa, Narumi, Satoshi, Nishimura, Riko, Kato‐Fukui, Yuko, Takada, Shuji, Hasegawa, Yukihiro, Fukami, Maki
Format: Article
Language:English
Subjects:
Sertoli cells
Sox9 protein
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Summary:This study provides supporting evidence for the association between SOX9 and liquid–liquid phase separation. We show that SOX9 colocalized with a paraspeckle protein NONO in many, but not all, of the immortalized and primary murine Sertoli cells examined. In addition, we confirmed that SOX9 has structural characteristics of intrinsically disordered proteins.
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.23425