Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum

We show that the intraerythrocytic stages of the malaria parasite Plasmodium falciparum bind plasminogen and mediate its conversion into plasmin to inactivate parasite‐bound C3b. This complement evasion mechanism counteracts terminal complex formation and hence promotes parasite survival in human bl...

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Bibliographic Details
Published in:European journal of immunology 2021-02, Vol.51 (2), p.490-493
Main Authors: Reiss, Timo, Theis, Hannah I., Gonzalez‐Delgado, Andres, Vega‐Rodriguez, Joel, Zipfel, Peter F., Skerka, Christine, Pradel, Gabriele
Format: Article
Language:English
Subjects:
Complement C3b - immunology
Complement component C3b
Complement system
Erythrocytes
Host-Parasite Interactions - immunology
Humans
Immune evasion
Immune Evasion - immunology
Malaria
Malaria, Falciparum - immunology
Malaria, Falciparum - parasitology
Parasites
Plasmin
plasminogen
Plasmodium falciparum
Plasmodium falciparum - immunology
Protozoa
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Summary:We show that the intraerythrocytic stages of the malaria parasite Plasmodium falciparum bind plasminogen and mediate its conversion into plasmin to inactivate parasite‐bound C3b. This complement evasion mechanism counteracts terminal complex formation and hence promotes parasite survival in human blood.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202048718