Zr‐MOF‐808 as Catalyst for Amide Esterification

In this work, zirconium‐based metal–organic framework Zr‐MOF‐808‐P has been found to be an efficient and versatile catalyst for amide esterification. Comparing with previously reported homogeneous and heterogeneous catalysts, Zr‐MOF‐808‐P can promote the reaction for a wide range of primary, seconda...

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Bibliographic Details
Published in:Chemistry : a European journal 2021-03, Vol.27 (14), p.4588-4598
Main Authors: Villoria‐del‐Álamo, Beatriz, Rojas‐Buzo, Sergio, García‐García, Pilar, Corma, Avelino
Format: Article
Language:English
Subjects:
Alcohols
Amides
Butanol
Catalysts
Chemistry
Esterification
heterogeneous catalysis
kinetics
Metal-organic frameworks
reaction mechanisms
Zirconium
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Summary:In this work, zirconium‐based metal–organic framework Zr‐MOF‐808‐P has been found to be an efficient and versatile catalyst for amide esterification. Comparing with previously reported homogeneous and heterogeneous catalysts, Zr‐MOF‐808‐P can promote the reaction for a wide range of primary, secondary and tertiary amides with n‐butanol as nucleophilic agent. Different alcohols have been employed in amide esterification with quantitative yields. Moreover, the catalyst acts as a heterogeneous catalyst and could be reused for at least five consecutive cycles. The amide esterification mechanism has been studied on the Zr‐MOF‐808 at molecular level by in situ FTIR spectroscopic technique and kinetic study. Zr‐MOF‐808‐P is shown as an efficient reusable heterogeneous catalyst for amide esterification with ample substrate scope. The reaction mechanism is studied by in situ FTIR spectroscopy.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202003752