Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?

Research with psychedelic drugs has mainly focused on isolated compounds. However, this approach is challenged by the “polypharmacology” paradigm. In this Viewpoint, we suggest that we may be missing something if we do not use the whole product in the case of ayahuasca or Psilocybe mushrooms. After...

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Bibliographic Details
Published in:ACS chemical neuroscience 2020-10, Vol.11 (20), p.3191-3193
Main Authors: Ona, Genı́s, Dos Santos, Rafael G, Hallak, Jaime E. C, Bouso, José Carlos
Format: Article
Language:English
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Summary:Research with psychedelic drugs has mainly focused on isolated compounds. However, this approach is challenged by the “polypharmacology” paradigm. In this Viewpoint, we suggest that we may be missing something if we do not use the whole product in the case of ayahuasca or Psilocybe mushrooms. After describing how research on psychedelic drugs can be effectively combined with the polypharmacology paradigm, ethical issues are also briefly discussed.
ISSN:1948-7193
1948-7193
DOI:10.1021/acschemneuro.0c00614