The Effect of Radiation Therapy on the Efficacy of Internal Urethrotomy With Intralesional Mitomycin C for Recurrent Vesicourethral Anastomotic Stenoses and Bladder Neck Contractures: A Multi-Institutional Experience

To assess the efficacy, effect of radiotherapy, and complications of direct visual internal urethrotomy (DVIU) and intralesional mitomycin C (MMC) for recurrent bladder neck contracture/vesicourethral anastomotic stenosis (BNC/VUAS). Patients who underwent DVIU with intralesional MMC for recurrent B...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2021-01, Vol.147, p.294-298
Main Authors: Rozanski, Alexander T., Zhang, Lawrence T., Holst, Daniel D., Copacino, Steven A., Vanni, Alex J., Buckley, Jill C.
Format: Article
Language:English
Subjects:
Aged
Anastomosis, Surgical - adverse effects
Combined Modality Therapy
Cryosurgery
Follow-Up Studies
Humans
Injections, Intralesional
Male
Mitomycin - administration & dosage
Recurrence
Retrospective Studies
Urethra - surgery
Urethral Stricture - drug therapy
Urethral Stricture - radiotherapy
Urinary Bladder Neck Obstruction - drug therapy
Urinary Bladder Neck Obstruction - radiotherapy
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Summary:To assess the efficacy, effect of radiotherapy, and complications of direct visual internal urethrotomy (DVIU) and intralesional mitomycin C (MMC) for recurrent bladder neck contracture/vesicourethral anastomotic stenosis (BNC/VUAS). Patients who underwent DVIU with intralesional MMC for recurrent BNC/VUAS between 2007 and 2019 at 2 institutions were included. Cold knife incisions were performed in a reproducible fashion followed by injection of 0.3-0.4 mg/mL MMC at each incision site. Those with evidence of complete urethral obliteration, stenosis of the entire posterior urethra, or 90% of nonradiated patients and >75% of radiated patients.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2020.09.035