Analysis of determinant factors of liver fibrosis progression in ex-thalassemic patients

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) potentially renders thalassemia patients disease-free with presumably cessation of associated complications. This study analyzes the liver fibrosis status and the determinants of its progression in ex-thalassemic patients. The liver fibr...

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Bibliographic Details
Published in:International journal of hematology 2021, Vol.113 (1), p.145-157
Main Authors: Rostami, Tahereh, Monzavi, Seyed Mostafa, Poustchi, Hossein, Khoshdel, Ali Reza, Behfar, Maryam, Hamidieh, Amir Ali
Format: Article
Language:English
Subjects:
Adolescent
Allografts
beta-Thalassemia - complications
beta-Thalassemia - therapy
Bone marrow
Bone marrow transplantation
Bone Marrow Transplantation - adverse effects
Child
Child, Preschool
Complications
Depletion
Disease Progression
Elasticity Imaging Techniques
Female
Ferritin
Fibrosis
Graft vs Host Disease - etiology
Graft-versus-host reaction
Hematology
Hematopoiesis
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Iron
Liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - etiology
Liver diseases
Liver transplantation
Male
Medicine
Medicine & Public Health
Oncology
Original Article
Prospective Studies
Stem cell transplantation
Stem cells
Thalassemia
Transfusion
Transplantation
Transplantation, Homologous
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Summary:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) potentially renders thalassemia patients disease-free with presumably cessation of associated complications. This study analyzes the liver fibrosis status and the determinants of its progression in ex-thalassemic patients. The liver fibrosis status of 108 pediatric transfusion-dependent β-thalassemia major patients was evaluated before and one year after allo-HSCT using transient elastography (TE). All patients achieved normal hematopoiesis. In univariate analyses, not in all, but in patients developing significant post-HSCT iron overload or hepatic graft-versus-host disease (GvHD), as well as recipients of bone marrow stem cells (BMSC), significant TE increment occurred. In multivariable analyses, through a model with large effect size (Adj. R 2  = 26%, F (3,104)  = 13.53, P  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-020-02998-4