Predictive value of vascular calcification identified in 4D planning CT of lung cancer patients treated with stereotactic body radiation therapy

•Thoracic vascular calcifications were identified on 4D planning CT scans of 334 lung cancer patients treated with SBRT.•Calcification volumes from inhale-exhale phases had the highest correlation with cardiac comorbidity.•The average of calcification volumes from inhale-exhale phases was predictor...

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Bibliographic Details
Published in:Physica medica 2020-10, Vol.78, p.173-178
Main Authors: Abravan, Azadeh, van Herk, Marcel, Brewster, Frank, Faivre-Finn, Corinne, McWilliam, Alan, Vasquez Osorio, Eliana M.
Format: Article
Language:English
Subjects:
4DCT
Adult
Cardiac comorbidity
Four-Dimensional Computed Tomography
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - radiotherapy
Myocardial infarction
Radiosurgery
Radiotherapy Planning, Computer-Assisted
Respiration
Stereotactic body radiation therapy
Vascular Calcification
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Summary:•Thoracic vascular calcifications were identified on 4D planning CT scans of 334 lung cancer patients treated with SBRT.•Calcification volumes from inhale-exhale phases had the highest correlation with cardiac comorbidity.•The average of calcification volumes from inhale-exhale phases was predictor of overall survival. The aim was to identify vascular calcification in 4DCT scan of lung cancer patients and establish the association between overall survival (OS) and vascular calcification, as surrogate for vascular health. Vascular calcification within the thoracic cavity were segmented in 334 lung cancer patients treated with stereotactic body radiation therapy (SBRT). This has been done automatically on 4D planning CT and average reconstruction scans. Correlation between cardiac comorbidity and calcification volumes was evaluated for patients with recorded Adult Co-Morbidity Evaluation (n = 303). Associations between the identified calcifications and OS were further investigated. The volume of calcification from the average scan was significantly lower than from each phase (p 
ISSN:1120-1797
1724-191X
DOI:10.1016/j.ejmp.2020.09.010