Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection

• Published in: Clinical infectious diseases 2021-07, Vol.73 (1), p.1-11
• Main Authors: Munblit, Daniel, Nekliudov, Nikita A, Bugaeva, Polina, Blyuss, Oleg, Kislova, Maria, Listovskaya, Ekaterina, Gamirova, Aysylu, Shikhaleva, Anastasia, Belyaev, Vladimir, Timashev, Peter, Warner, John O, Comberiati, Pasquale, Apfelbacher, Christian, Bezrukov, Evgenii, Politov, Mikhail E, Yavorovskiy, Andrey, Bulanova, Ekaterina, Tsareva, Natalya, Avdeev, Sergey, Kapustina, Valentina A, Pigolkin, Yuri I, Dankwa, Emmanuelle A, Kartsonaki, Christiana, Pritchard, Mark G, Fomin, Victor, Svistunov, Andrey A, Butnaru, Denis, Glybochko, Petr, Berbenyuk, Anna, Bobkova, Polina, Bordyugov, Semyon, Borisenko, Aleksandra, Bugaiskaya, Ekaterina, Druzhkova, Olesya, Eliseev, Dmitry, El-Taravi, Yasmin, Gorbova, Natalia, Gribaleva, Elizaveta, Grigoryan, Rina, Ibragimova, Shabnam, Kabieva, Khadizhat, Khrapkova, Alena, Kogut, Natalia, Kovygina, Karina, Kvaratskheliya, Margaret, Lobova, Maria, Lunicheva, Anna, Maystrenko, Anastasia, Nikolaeva, Daria, Pavlenko, Anna, Perekosova, Olga, Romanova, Olga, Sokova, Olga, Solovieva, Veronika, Spasskaya, Olga, Spiridonova, Ekaterina, Sukhodolskaya, Olga, Suleimanov, Shakir, Urmantaeva, Nailya, Usalka, Olga, Zaikina, Margarita, Zorina, Anastasia, Khitrina, Nadezhda
• Format: Article
• Language: English
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/cid/ciaa1535

BACKGROUNDThe epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking. METHODSWe extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020. RESULTSOf the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45-66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase-polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03-1.06), male sex (1.71; 1.24-2.37), chronic kidney disease (2.99; 1.89-4.64), diabetes (2.1; 1.46-2.99), chronic cardiovascular disease (1.78; 1.24-2.57), and dementia (2.73; 1.34-5.47). CONCLUSIONSAge, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.