Focal adhesion kinase: Insight into its roles and therapeutic potential in oesophageal cancer

Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of

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Bibliographic Details
Published in:Cancer letters 2021-01, Vol.496, p.93-103
Main Authors: Zhang, Yumeng, Liu, Shu, Zhou, Shu, Yu, Dandan, Gu, Junjie, Qin, Qin, Cheng, Yu, Sun, Xinchen
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Binding sites
Cancer
Cancer therapies
Cell adhesion & migration
Cell cycle
Cell growth
Chemotherapy
DNA damage
DNA repair
Esophageal cancer
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
Esophagus
Focal adhesion kinase
Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors
Gene Expression Regulation, Enzymologic - drug effects
Gene Expression Regulation, Neoplastic - drug effects
Growth factors
Humans
Immunotherapy
Invasiveness
Kinases
Medical prognosis
Mesenchyme
Metastases
Molecular Targeted Therapy
Morbidity
Mortality
Oesophageal cancer
Phosphorylation
Protein Kinase Inhibitors - therapeutic use
Protein-tyrosine kinase receptors
Proteins
Radiation therapy
Radioresistance
Signal transduction
Solid tumors
Targeted therapy
Tumors
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Description
Summary:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2020.10.005