Plasma microRNA levels in childhood IgA vasculitis

Introduction Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18–25 base-long non-coding RNA group acting on ge...

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Bibliographic Details
Published in:Clinical rheumatology 2021-05, Vol.40 (5), p.1975-1981
Main Authors: Cebi, Alper Han, Demir, Ferhat, Ikbal, Mevlit, Kalyoncu, Mukaddes
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biomarkers
Child
Childhood
Children
Gastrointestinal tract
Gene expression
Humans
Immune system
Immunoglobulin A
Medicine
Medicine & Public Health
MicroRNAs
miRNA
Non-coding RNA
Original Article
Pathogenesis
Purpura, Schoenlein-Henoch
Rheumatology
Systemic vasculitis
Vasculitis
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Summary:Introduction Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18–25 base-long non-coding RNA group acting on gene expression. They have been shown to be effective on the immune system studies to date. Method In our study, 24 IgAV children with skin and joint involvement and 24 healthy children were included. Five different miRNAs (miR-33, miR-34, miR-122, miR-204, and miR451) known to be expressed in plasma and related with autoimmunity pathogenesis were evaluated. miRNAs were compared between the active period of the disease, the post-treatment period, and the healthy group using the real-time PCR method. Results Expression levels of miRNA-33 and miRNA-34 increased significantly in active period of the patients compare with inactive period and control groups. The expression levels of miRNA-122 and miRNA-204 decreased significantly in active period of the patients compare with other two groups. There was no significant difference in miRNA-451 levels. Conclusions With the experience we gained from our recent studies, we think that miRNA-204 may be a significant biomarker in autoimmune diseases. Our study is the first study between IgAV and miRNAs in children. More studies are needed to reveal this relationship. Key Points • This is the first paper to show the relationship between miRNAs and childhood IgAV. • It will provide a new perspective to evaluate the pathogenesis of the disease.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-020-05441-5