Colocalization of tracks from boron neutron capture reactions and images of isolated cells

In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tr...

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Bibliographic Details
Published in:Applied radiation and isotopes 2021-01, Vol.167, p.109353-109353, Article 109353
Main Authors: Postuma, Ian, Sommi, Patrizia, Vitali, Agostina, Shu, Diyun, Martino, Greta di, Cansolino, Laura, Ferrari, Cinzia, Ricci, Vittorio, Magni, Chiara, Protti, Nicoletta, Fatemi, Setareh, Tamburini, Umberto Anselmi, Bortolussi, Silva, Altieri, Saverio
Format: Article
Language:English
Subjects:
BNCT
Boron
Cell cultures
Neutron autoradiography
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Summary:In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector. •Overlay of tracks from the 10B (n,α)7Li reaction over cells.•An affordable technique to study newly formulated 10B drugs.•Cells can be seeded directly on a CR39.•High resolution autoradiography limited by track diameter of ≈ 1 μm.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2020.109353