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Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease
To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD). This cohort study using the Parkinson's Progression Markers Initiative data included 405 patients with early PD. They were classified into late-onset (age at onset ≥ 70 y...
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| Published in: | Journal of the neurological sciences 2020-11, Vol.418, p.117157-117157, Article 117157 |
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| container_title | Journal of the neurological sciences |
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| creator | Kim, Ryul Shin, Jung Hwan Park, Sangmin Kim, Han-Joon Jeon, Beomseok |
| description | To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD).
This cohort study using the Parkinson's Progression Markers Initiative data included 405 patients with early PD. They were classified into late-onset (age at onset ≥ 70 years, n = 63), middle-onset (50 to 69 years, n = 268), and young-onset ( |
| doi_str_mv | 10.1016/j.jns.2020.117157 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449993000</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022510X20304937</els_id><sourcerecordid>2449993000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-b5da8dc67767ce6cf16283e1bacc4ac2a3c25620ac2a95a9711cc038a1dbbbcf3</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhoMo7rj6A7xIbnrpMR_T3QmeZPELBvSg4C2kq6uHjN3JmEovzL83w6wePVUVPPUW9TD2UoqtFLJ7e9weI22VUHWWvWz7R2wjTW-a1hj9mG2EUKpppfh5w54RHYUQnTH2KbvRWmhr-27DYJ_iIZR1DNHPHO_TvJaQIk8Tjyk2Syopczovp5IW4h4g5YoeeEncH5D7wlMkLDxEjj7PZ_7N518hUoqviY-B0BM-Z08mPxO-eKi37MfHD9_vPjf7r5--3L3fN7CTtjRDO3ozQtf3XQ_YwSQ7ZTTKoV7deVBeg2o7JS6tbb3tpQQQ2ng5DsMAk75lb665p5x-r0jFLYEA59lHTCs5tdtZa3XVUFF5RSEnooyTO-Ww-Hx2UriLW3d01a27uHVXt3Xn1UP8Oiw4_tv4K7MC764A1ifvA2ZHEDACjiEjFDem8J_4P2sujBo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449993000</pqid></control><display><type>article</type><title>Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease</title><source>ScienceDirect Freedom Collection</source><creator>Kim, Ryul ; Shin, Jung Hwan ; Park, Sangmin ; Kim, Han-Joon ; Jeon, Beomseok</creator><creatorcontrib>Kim, Ryul ; Shin, Jung Hwan ; Park, Sangmin ; Kim, Han-Joon ; Jeon, Beomseok</creatorcontrib><description>To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD).
This cohort study using the Parkinson's Progression Markers Initiative data included 405 patients with early PD. They were classified into late-onset (age at onset ≥ 70 years, n = 63), middle-onset (50 to 69 years, n = 268), and young-onset (<50 years, n = 74) groups. Non-motor symptoms were assessed with well-validated instruments covering neuropsychiatric, sleep-related, and autonomic symptoms yearly over 5 years of follow-up. Dopamine transporter imaging was also performed at baseline and the 1-, 2-, and 4-year follow-up visits.
The late-onset group had a mean decrease of 0.35 more points per year in the Montreal Cognitive Assessment (MoCA) scores (p = 0.008) and increases of 0.32 more points in the 15-item Geriatric Depression Scale scores (p = 0.002) and 0.72 more points in the State-Trait Anxiety Inventory-state scores (p = 0.022) compared to the middle-onset group. The young-onset group had a mean decrease of 0.22 fewer points per year in the MoCA scores (p = 0.002) than the middle-onset group. The other non-motor progression did not differ among the groups. No significant differences were found between the late-onset, middle-onset, and young-onset groups in the changes of striatal DAT binding ratios.
Compared to middle-onset PD, late-onset PD showed a faster progression of cognitive impairment along with depression and anxiety, and young-onset PD showed a slower progression of cognitive impairment in the early phases of the disease. These differences do not appear to be associated with the longitudinal changes in striatal dopaminergic activities.
•Late-onset PD showed faster decline in cognitive impairment, depression, and anxiety compared to middle-onset PD.•Young-onset PD showed a slower progression of cognitive impairment compared to middle-onset PD.•These differences do not appear to be related to the longitudinal changes in striatal dopaminergic activities.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2020.117157</identifier><identifier>PMID: 33039976</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age at onset ; Age of Onset ; Aged ; Anxiety - epidemiology ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - epidemiology ; Cohort Studies ; Humans ; Late-onset ; Non-motor symptom ; Parkinson Disease - complications ; Parkinson Disease - epidemiology ; Parkinson's disease ; Young-onset</subject><ispartof>Journal of the neurological sciences, 2020-11, Vol.418, p.117157-117157, Article 117157</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-b5da8dc67767ce6cf16283e1bacc4ac2a3c25620ac2a95a9711cc038a1dbbbcf3</citedby><cites>FETCH-LOGICAL-c419t-b5da8dc67767ce6cf16283e1bacc4ac2a3c25620ac2a95a9711cc038a1dbbbcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33039976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ryul</creatorcontrib><creatorcontrib>Shin, Jung Hwan</creatorcontrib><creatorcontrib>Park, Sangmin</creatorcontrib><creatorcontrib>Kim, Han-Joon</creatorcontrib><creatorcontrib>Jeon, Beomseok</creatorcontrib><title>Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD).
This cohort study using the Parkinson's Progression Markers Initiative data included 405 patients with early PD. They were classified into late-onset (age at onset ≥ 70 years, n = 63), middle-onset (50 to 69 years, n = 268), and young-onset (<50 years, n = 74) groups. Non-motor symptoms were assessed with well-validated instruments covering neuropsychiatric, sleep-related, and autonomic symptoms yearly over 5 years of follow-up. Dopamine transporter imaging was also performed at baseline and the 1-, 2-, and 4-year follow-up visits.
The late-onset group had a mean decrease of 0.35 more points per year in the Montreal Cognitive Assessment (MoCA) scores (p = 0.008) and increases of 0.32 more points in the 15-item Geriatric Depression Scale scores (p = 0.002) and 0.72 more points in the State-Trait Anxiety Inventory-state scores (p = 0.022) compared to the middle-onset group. The young-onset group had a mean decrease of 0.22 fewer points per year in the MoCA scores (p = 0.002) than the middle-onset group. The other non-motor progression did not differ among the groups. No significant differences were found between the late-onset, middle-onset, and young-onset groups in the changes of striatal DAT binding ratios.
Compared to middle-onset PD, late-onset PD showed a faster progression of cognitive impairment along with depression and anxiety, and young-onset PD showed a slower progression of cognitive impairment in the early phases of the disease. These differences do not appear to be associated with the longitudinal changes in striatal dopaminergic activities.
•Late-onset PD showed faster decline in cognitive impairment, depression, and anxiety compared to middle-onset PD.•Young-onset PD showed a slower progression of cognitive impairment compared to middle-onset PD.•These differences do not appear to be related to the longitudinal changes in striatal dopaminergic activities.</description><subject>Age at onset</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Anxiety - epidemiology</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cohort Studies</subject><subject>Humans</subject><subject>Late-onset</subject><subject>Non-motor symptom</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Young-onset</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE2LFDEQhoMo7rj6A7xIbnrpMR_T3QmeZPELBvSg4C2kq6uHjN3JmEovzL83w6wePVUVPPUW9TD2UoqtFLJ7e9weI22VUHWWvWz7R2wjTW-a1hj9mG2EUKpppfh5w54RHYUQnTH2KbvRWmhr-27DYJ_iIZR1DNHPHO_TvJaQIk8Tjyk2Syopczovp5IW4h4g5YoeeEncH5D7wlMkLDxEjj7PZ_7N518hUoqviY-B0BM-Z08mPxO-eKi37MfHD9_vPjf7r5--3L3fN7CTtjRDO3ozQtf3XQ_YwSQ7ZTTKoV7deVBeg2o7JS6tbb3tpQQQ2ng5DsMAk75lb665p5x-r0jFLYEA59lHTCs5tdtZa3XVUFF5RSEnooyTO-Ww-Hx2UriLW3d01a27uHVXt3Xn1UP8Oiw4_tv4K7MC764A1ifvA2ZHEDACjiEjFDem8J_4P2sujBo</recordid><startdate>20201115</startdate><enddate>20201115</enddate><creator>Kim, Ryul</creator><creator>Shin, Jung Hwan</creator><creator>Park, Sangmin</creator><creator>Kim, Han-Joon</creator><creator>Jeon, Beomseok</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201115</creationdate><title>Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease</title><author>Kim, Ryul ; Shin, Jung Hwan ; Park, Sangmin ; Kim, Han-Joon ; Jeon, Beomseok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-b5da8dc67767ce6cf16283e1bacc4ac2a3c25620ac2a95a9711cc038a1dbbbcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age at onset</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Anxiety - epidemiology</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cohort Studies</topic><topic>Humans</topic><topic>Late-onset</topic><topic>Non-motor symptom</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Young-onset</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ryul</creatorcontrib><creatorcontrib>Shin, Jung Hwan</creatorcontrib><creatorcontrib>Park, Sangmin</creatorcontrib><creatorcontrib>Kim, Han-Joon</creatorcontrib><creatorcontrib>Jeon, Beomseok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ryul</au><au>Shin, Jung Hwan</au><au>Park, Sangmin</au><au>Kim, Han-Joon</au><au>Jeon, Beomseok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2020-11-15</date><risdate>2020</risdate><volume>418</volume><spage>117157</spage><epage>117157</epage><pages>117157-117157</pages><artnum>117157</artnum><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD).
This cohort study using the Parkinson's Progression Markers Initiative data included 405 patients with early PD. They were classified into late-onset (age at onset ≥ 70 years, n = 63), middle-onset (50 to 69 years, n = 268), and young-onset (<50 years, n = 74) groups. Non-motor symptoms were assessed with well-validated instruments covering neuropsychiatric, sleep-related, and autonomic symptoms yearly over 5 years of follow-up. Dopamine transporter imaging was also performed at baseline and the 1-, 2-, and 4-year follow-up visits.
The late-onset group had a mean decrease of 0.35 more points per year in the Montreal Cognitive Assessment (MoCA) scores (p = 0.008) and increases of 0.32 more points in the 15-item Geriatric Depression Scale scores (p = 0.002) and 0.72 more points in the State-Trait Anxiety Inventory-state scores (p = 0.022) compared to the middle-onset group. The young-onset group had a mean decrease of 0.22 fewer points per year in the MoCA scores (p = 0.002) than the middle-onset group. The other non-motor progression did not differ among the groups. No significant differences were found between the late-onset, middle-onset, and young-onset groups in the changes of striatal DAT binding ratios.
Compared to middle-onset PD, late-onset PD showed a faster progression of cognitive impairment along with depression and anxiety, and young-onset PD showed a slower progression of cognitive impairment in the early phases of the disease. These differences do not appear to be associated with the longitudinal changes in striatal dopaminergic activities.
•Late-onset PD showed faster decline in cognitive impairment, depression, and anxiety compared to middle-onset PD.•Young-onset PD showed a slower progression of cognitive impairment compared to middle-onset PD.•These differences do not appear to be related to the longitudinal changes in striatal dopaminergic activities.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33039976</pmid><doi>10.1016/j.jns.2020.117157</doi><tpages>1</tpages></addata></record> |
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| subjects | Age at onset Age of Onset Aged Anxiety - epidemiology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology Cohort Studies Humans Late-onset Non-motor symptom Parkinson Disease - complications Parkinson Disease - epidemiology Parkinson's disease Young-onset |
| title | Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease |
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