Quantitative and objective diagnosis of color vision deficiencies based on steady-state visual evoked potentials

Purpose Traditional color vision tests depend on subjective judgments and are not suitable for infant children and subjects with cognitive dysfunction. We aimed to explore an objective and quantitative color vision testing method based on sweep steady-state visual evoked potentials (sweep SSVEPs) an...

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Bibliographic Details
Published in:International ophthalmology 2021-02, Vol.41 (2), p.587-598
Main Authors: Zheng, Xiaowei, Xu, Guanghua, Wang, Yunyun, Du, Chenghang, Liang, Renghao, Zhang, Kai, Jia, Yaguang, Du, Yuhui, Zhang, Sicong
Format: Article
Language:English
Subjects:
Classification
Cognitive ability
Color blindness
Color vision
Cones
Correlation analysis
Diagnosis
EEG
Electroencephalography
Evoked potentials
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Primates
Psychophysics
Quantitative analysis
Signal processing
Steady state
Visual evoked potentials
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Summary:Purpose Traditional color vision tests depend on subjective judgments and are not suitable for infant children and subjects with cognitive dysfunction. We aimed to explore an objective and quantitative color vision testing method based on sweep steady-state visual evoked potentials (sweep SSVEPs) and compare the results with subjective Farnsworth–Munsell (FM) 100-hue test results. Methods A red-green SSVEP pattern reversal checkboard paradigm at different luminance ratios was used to induce visual evoked potentials (VEPs) from 15 color vision deficiencies (CVDs) and 11 normal color vision subjects. After electroencephalography signals were processed by canonical correlation analysis, an equiluminance turning curve corresponding to the activation of the L -cones and M -cones at different levels of color vision was established. Then, we obtained different equiluminance T and proposed the SSVEP color vision severity index ( I CVD ) to quantify color vision function and the severity of CVDs. In addition, the FM 100-hue test was used to obtain subjective data for the diagnosis of color vision. Results The value of I CVD can be an indicator of the level of color vision. Both the total error scores (TES) and confusion index ( C -index) of the FM 100-hue test were significantly correlated with I CVD values ( P  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-020-01613-z