Infrapopliteal endovascular intervention and the angiosome concept: intraoperative real-time assessment of foot regions’ blood volume guides and improves direct revascularization

• Published in: European radiology 2021-04, Vol.31 (4), p.2144-2152
• Main Authors: Ma, Jiangyu, Lai, Zhichao, Shao, Jiang, Lei, Jinsong, Li, Kang, Wang, Jingjing, Xu, Leyin, Fang, Lijing, Yu, Xiaoxi, Qi, Wanting, Wang, Chaonan, Cao, Wenteng, Liu, Xiaolong, Yuan, Jinghui, Liu, Bao
• Format: Article
• Language: English
• Subjects: Amputation; Arteries; Blood; Blood circulation; Blood vessels; Blood Volume; Cardiovascular system; Diagnostic Radiology; Endovascular Procedures; Feet; Flat panels; Humans; Imaging; Internal Medicine; Intervention; Interventional Radiology; Ischemia; Ischemia - surgery; Limb Salvage; Medicine; Medicine & Public Health; Neuroradiology; Patients; Perfusion; Prospective Studies; Radiology; Regional Blood Flow; Retrospective Studies; Supplying; Surgery; Treatment Outcome; Ultrasound; Vascular-Interventional; Wound Healing
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-020-07360-0

Objective There is no consensus for determining which vessel should be revascularized in patients with multiple diseased infrapopliteal arteries. The angiosome concept may guide a more efficient targeted direct revascularization. Therefore, we conducted a study to assess whether the regional evaluation of foot blood volume may guide direct revascularization (DR) and if it will lead to better perfusion improvement than indirect revascularization (IR). Methods We performed a prospective single-center observational cohort study in patients treated in the Department of Vascular Surgery of Peking Union Medical College Hospital from November 2016 to April 2019. Twenty-seven patients treated with endovascular intervention were included. The intraoperative parenchymal blood volume of different foot regions was obtained for each patient using C-arm CT before and after intervention. Results The intervention procedure significantly increased the overall blood volume (48.95 versus 81.97 ml/1000 ml, p = 0.002). Patients with direct revascularization had a 197% blood volume increase while patients with indirect revascularization had a 39% increase ( p = 0.028). The preoperative blood volume was higher in patients with mild symptoms than in patients with severe symptoms (58.20 versus 30.45 ml/1000 ml, p = 0.039). However, in regard to postoperative blood volume, no significant difference was discovered between these two groups (75.05 versus 95.01 ml/1000 ml, p = 0.275). Conclusion Based on quantitative measurements, we conclude that overall blood volume can rise significantly after the intervention. Revascularizing the supplying vessel of the ischemic area directly will result in better perfusion improvement than restoring blood supply through the collateral circulation. Preoperative blood volume is associated with preoperative symptoms. Key Points • Flat panel detector CT can obtain intraoperative perfusion status and guide treatment in endovascular intervention. • Revascularizing the supplying vessel of the ischemic area directly will result in better perfusion improvement than restoring the blood supply through the collateral circulation. • Patients with severer clinical manifestations have lower blood volumes.