Is hypervascular papillary renal cell carcinoma present?

Purpose We aimed to investigate atypical papillary renal cell carcinoma (PRCC) presenting with early contrast enhancement and late washout and to investigate the correlation between the CT attenuation value of the corticomedullary phase (CMP) of contrast-enhanced CT in PRCCs and the endothelial cell...

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Bibliographic Details
Published in:Abdominal imaging 2021-04, Vol.46 (4), p.1687-1693
Main Authors: Yamamoto, Tatsuya, Gulanbar, Amori, Hayashi, Kuniyoshi, Kohno, Atsushi, Komai, Yoshinobu, Yonese, Junji, Matsueda, Kiyoshi, Inamura, Kentaro
Format: Article
Language:English
Subjects:
Antibodies
Attenuation
Bladder
Clear cell-type renal cell carcinoma
Endothelial cells
Gastroenterology
Hepatology
Imaging
Kidney cancer
Kidneys
Magnetic resonance imaging
Medical diagnosis
Medicine
Medicine & Public Health
Papillary renal cell carcinoma
Radiology
Regression analysis
Retroperitoneum
Tumors
Ureters
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Summary:Purpose We aimed to investigate atypical papillary renal cell carcinoma (PRCC) presenting with early contrast enhancement and late washout and to investigate the correlation between the CT attenuation value of the corticomedullary phase (CMP) of contrast-enhanced CT in PRCCs and the endothelial cell counts of these tumors. Methods Twenty-two patients with pathologically confirmed PRCC were enrolled in this study. PRCCs were categorized into 18 typical PRCCs and 4 atypical PRCCs. The CT attenuation value of the lesion in the CMP was measured in the maximal section of the tumor using the region of interest. Microvessel density (MVD) was evaluated as a histopathologic parameter using tissue specimens immunohistochemically stained with an anti-ERG antibody. The CT attenuation value and MVD were compared between atypical and typical PRCCs using the Mann–Whitney U test, where p < 0.05 was considered significant. The correlations between CT attenuation value and MVD were evaluated in all PRCCs using single linear regression analysis. Results The mean CT attenuation value and the MVD were significantly higher in atypical than in typical PRCCs. Correlation analyses revealed a weak positive correlation between the CT attenuation value and MVD. Conclusions We confirmed several cases of atypical PRCC that present with early contrast enhancement, such as clear cell renal cell carcinoma. In addition, a positive correlation was found between the CT attenuation value in the CMP of PRCCs and the vascular endothelial cell count.
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-020-02809-8