Effects of mesenchymal stem cells transplantation on multiple sclerosis patients

Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS) with symptoms such as neuroinflammation and axonal degeneration. Existing drugs help reduce inflammatory conditions and protect CNS from demyelination and axonal damage; however, these drugs are unable...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2020-12, Vol.84, p.102095-102095, Article 102095
Main Authors: Barati, Shirin, Tahmasebi, Fatemeh, Faghihi, Faeze
Format: Article
Language:English
Subjects:
Autoimmune diseases
Cell therapy
Central nervous system
Demyelination
Immunomodulation
Immunosuppressive agents
Inflammation
Mesenchymal stem cells
Multiple sclerosis
Myelination
Neurodegeneration
Neuroprotection
Patients
Regenerative medicine
Stem cells
Transplantation
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Summary:Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS) with symptoms such as neuroinflammation and axonal degeneration. Existing drugs help reduce inflammatory conditions and protect CNS from demyelination and axonal damage; however, these drugs are unable to enhance axonal repair and remyelination. In this regard, cell therapy is considered as a promising regenerative approach to MS treatment. High immunomodulatory capacity, neuro-differentiation and neuroprotection properties have made Mesenchymal Stem Cells (MSCs) particularly useful for regenerative medicine. There are scant studies on the role of MSCs in patients suffering from MS. The low number of MS patients and the lack of control groups in these studies may explain the lack of beneficial effects of MSC transplantation in cell therapies. In this review, we evaluated the beneficial effects of MSC transplantation in clinical studies in terms of immunomodulatory, remyelinating and neuroprotecting properties of MSCs.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2020.102095