Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-Related Central and Peripheral Hearing Loss in a Southern Italian Older Population

Abstract Background Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these 2 conditions in older age. We aimed to determine whether superficial and deep vascular density (SVD and DVD) of the capilla...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-12, Vol.76 (12), p.2169-2177
Main Authors: Sardone, Rodolfo, Sborgia, Giancarlo, Niro, Alfredo, Giuliani, Gianluigi, Pascale, Angelo, Puzo, Pasquale, Guerra, Vito, Castellana, Fabio, Lampignano, Luisa, Donghia, Rossella, Bortone, Ilaria, Zupo, Roberta, Griseta, Chiara, Logroscino, Giancarlo, Lozupone, Madia, Giannelli, Gianluigi, Panza, Francesco, Boscia, Francesco, Alessio, Giovanni, Quaranta, Nicola
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Angiography
Blood vessels
Center and periphery
Cross-Sectional Studies
Deafness
Dementia
Dementia disorders
Ear
Ears & hearing
Eye
Fluorescein Angiography
Gerontology
Hearing
Hearing Loss
Humans
Information processing
Italy
Microvascular Density
Neurodegeneration
Older people
Retina
Retina - diagnostic imaging
Retinal Vessels - diagnostic imaging
Tomography
Tomography, Optical Coherence
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Summary:Abstract Background Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these 2 conditions in older age. We aimed to determine whether superficial and deep vascular density (SVD and DVD) of the capillary plexi of macular vasculature can be associated with peripheral ARHL and age-related central auditory central processing (CAPD). Method We analyzed data on 886 older participants (65 years+, age range: 65–92 years) in the cross-sectional population-based Salus in Apulia Study. Optical coherence tomography angiography was used to measure SVD and DVD of the capillary plexi of the macula at the 3-mm circle area centered on the fovea (whole retina), the parafoveal quadrant, and foveal quadrant. Disabling peripheral ARHL was defined as >40 dB hearing level of pure tone average on the frequencies from 0.5, 1, 2, and 4 KHz in the better ear, and age-related CAPD as
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glaa269