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Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study
Introduction The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor and vasodilatory molecules in obese hypertensive patients und...
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| Published in: | Clinical endocrinology (Oxford) 2021-02, Vol.94 (2), p.193-203 |
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| creator | Salman, Ahmed Abdallah Salman, Mohamed Abdalla Shawkat, Mohamed Hassan, Shady A. Saad, Eman H. Hussein, Ahmed Mahmoud Refaie, Osama R. M. Tourky, Mohamed Sabry Shaaban, Hossam El‐Din Abd Allah, Nesrin El Domiaty, Heba Fathy Elkassar, Hesham |
| description | Introduction
The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor and vasodilatory molecules in obese hypertensive patients undergoing laparoscopic sleeve gastrectomy (LSG).
Patients
The present prospective study was done on 59 hypertensive obese patients in whom LGS was performed. Blood pressure, as well as blood samples for neprilysin, angiotensinogen, angiotensin II, renin, endothelin‐1 "ET‐1", aldosterone, atrial natriuretic peptide "ANP" and B‐type natriuretic peptide "BNP", were assessed before and 15 months after surgery. Patients were divided into two groups according to the remission of hypertension (HTN).
Results
After 15 months, remission of hypertension was seen in 42 patients (71%). The declines in the following measurements were significantly higher in patients with remission than those with persistent HTN: aldosterone (p = .029567), angiotensin II (p |
| doi_str_mv | 10.1111/cen.14352 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2451857710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2451857710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-ccaef9f46de01b2cefb3e27be3ac2235206243c4353b13c6dc4937320a2e1a0a3</originalsourceid><addsrcrecordid>eNp1kT9PwzAQxS0EoqUw8AWQJRYYQs924qRsVVX-SBUsMEeOc4FUaRxipyjfHpcUBiS8eHi_e7p3j5BzBjfMv6nG-oaFIuIHZMyEjALOZXRIxiAAApAyHJETa9cAECUQH5ORECDDRM7GpFsWBWpHTUEr1ajWWG2aUlNbIW6RvinrWq-bTU9NTbfKGqVd6ZUN5qVyprW0rKnJ0CJ97xtsHdZ2pzfKlVg7e0vntPG2DQ5z1nV5f0qOClVZPNv_E_J6t3xZPASr5_vHxXwVaBEJHmitsJgVocwRWMY1FplAHmcolObc5wXJQ6F9cpExoWWuw5mIBQfFkSlQYkKuBl-_wUeH1qWb0mqsKlWj6WzKw4glURwz8OjlH3Rturb223kqjmfAkkR66nqgtI9kWyzSpi03qu1TBumui9R3kX534dmLvWOX-Wv9kj_H98B0AD7LCvv_ndLF8mmw_AJwNJS0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2477901886</pqid></control><display><type>article</type><title>Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Salman, Ahmed Abdallah ; Salman, Mohamed Abdalla ; Shawkat, Mohamed ; Hassan, Shady A. ; Saad, Eman H. ; Hussein, Ahmed Mahmoud ; Refaie, Osama R. M. ; Tourky, Mohamed Sabry ; Shaaban, Hossam El‐Din ; Abd Allah, Nesrin ; El Domiaty, Heba Fathy ; Elkassar, Hesham</creator><creatorcontrib>Salman, Ahmed Abdallah ; Salman, Mohamed Abdalla ; Shawkat, Mohamed ; Hassan, Shady A. ; Saad, Eman H. ; Hussein, Ahmed Mahmoud ; Refaie, Osama R. M. ; Tourky, Mohamed Sabry ; Shaaban, Hossam El‐Din ; Abd Allah, Nesrin ; El Domiaty, Heba Fathy ; Elkassar, Hesham</creatorcontrib><description>Introduction
The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor and vasodilatory molecules in obese hypertensive patients undergoing laparoscopic sleeve gastrectomy (LSG).
Patients
The present prospective study was done on 59 hypertensive obese patients in whom LGS was performed. Blood pressure, as well as blood samples for neprilysin, angiotensinogen, angiotensin II, renin, endothelin‐1 "ET‐1", aldosterone, atrial natriuretic peptide "ANP" and B‐type natriuretic peptide "BNP", were assessed before and 15 months after surgery. Patients were divided into two groups according to the remission of hypertension (HTN).
Results
After 15 months, remission of hypertension was seen in 42 patients (71%). The declines in the following measurements were significantly higher in patients with remission than those with persistent HTN: aldosterone (p = .029567), angiotensin II (p < .000001), angiotensinogen (p = .000021), neprilysin (p = .000601), renin (p = .000454) and endothelin‐1(p = .000030). There was a significantly higher increment in ANP (p = .000002) and a non‐significant increment in BNP (p = .081740). Angiotensin II 15 months after LSG and Δ ANP % were significant independent predictors of persistent HTN.
Conclusion
In the setting of LSG, aldosterone, angiotensinogen, angiotensin II, renin and neprilysin were significantly lower in patients with remission of HTN after 15 months than those with persistent HTN, and natriuretic peptides were significantly higher. A lower postoperative level of angiotensin II and a larger percentage increment of ANP are independently associated with hypertension remission after LSG.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14352</identifier><identifier>PMID: 33064869</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aldosterone ; Angiotensin ; Angiotensin II ; Angiotensinogen ; Atrial natriuretic peptide ; Blood pressure ; Endothelins ; Gastrectomy ; Hypertension ; laparoscopic sleeve gastrectomy ; Laparoscopy ; Neprilysin ; Obesity ; Peptides ; Remission ; Renin ; Surgery ; Vasoactive agents ; vasoactive mediators</subject><ispartof>Clinical endocrinology (Oxford), 2021-02, Vol.94 (2), p.193-203</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-ccaef9f46de01b2cefb3e27be3ac2235206243c4353b13c6dc4937320a2e1a0a3</citedby><cites>FETCH-LOGICAL-c3532-ccaef9f46de01b2cefb3e27be3ac2235206243c4353b13c6dc4937320a2e1a0a3</cites><orcidid>0000-0003-0026-0841 ; 0000-0002-4783-258X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33064869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salman, Ahmed Abdallah</creatorcontrib><creatorcontrib>Salman, Mohamed Abdalla</creatorcontrib><creatorcontrib>Shawkat, Mohamed</creatorcontrib><creatorcontrib>Hassan, Shady A.</creatorcontrib><creatorcontrib>Saad, Eman H.</creatorcontrib><creatorcontrib>Hussein, Ahmed Mahmoud</creatorcontrib><creatorcontrib>Refaie, Osama R. M.</creatorcontrib><creatorcontrib>Tourky, Mohamed Sabry</creatorcontrib><creatorcontrib>Shaaban, Hossam El‐Din</creatorcontrib><creatorcontrib>Abd Allah, Nesrin</creatorcontrib><creatorcontrib>El Domiaty, Heba Fathy</creatorcontrib><creatorcontrib>Elkassar, Hesham</creatorcontrib><title>Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Introduction
The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor and vasodilatory molecules in obese hypertensive patients undergoing laparoscopic sleeve gastrectomy (LSG).
Patients
The present prospective study was done on 59 hypertensive obese patients in whom LGS was performed. Blood pressure, as well as blood samples for neprilysin, angiotensinogen, angiotensin II, renin, endothelin‐1 "ET‐1", aldosterone, atrial natriuretic peptide "ANP" and B‐type natriuretic peptide "BNP", were assessed before and 15 months after surgery. Patients were divided into two groups according to the remission of hypertension (HTN).
Results
After 15 months, remission of hypertension was seen in 42 patients (71%). The declines in the following measurements were significantly higher in patients with remission than those with persistent HTN: aldosterone (p = .029567), angiotensin II (p < .000001), angiotensinogen (p = .000021), neprilysin (p = .000601), renin (p = .000454) and endothelin‐1(p = .000030). There was a significantly higher increment in ANP (p = .000002) and a non‐significant increment in BNP (p = .081740). Angiotensin II 15 months after LSG and Δ ANP % were significant independent predictors of persistent HTN.
Conclusion
In the setting of LSG, aldosterone, angiotensinogen, angiotensin II, renin and neprilysin were significantly lower in patients with remission of HTN after 15 months than those with persistent HTN, and natriuretic peptides were significantly higher. A lower postoperative level of angiotensin II and a larger percentage increment of ANP are independently associated with hypertension remission after LSG.</description><subject>Aldosterone</subject><subject>Angiotensin</subject><subject>Angiotensin II</subject><subject>Angiotensinogen</subject><subject>Atrial natriuretic peptide</subject><subject>Blood pressure</subject><subject>Endothelins</subject><subject>Gastrectomy</subject><subject>Hypertension</subject><subject>laparoscopic sleeve gastrectomy</subject><subject>Laparoscopy</subject><subject>Neprilysin</subject><subject>Obesity</subject><subject>Peptides</subject><subject>Remission</subject><subject>Renin</subject><subject>Surgery</subject><subject>Vasoactive agents</subject><subject>vasoactive mediators</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kT9PwzAQxS0EoqUw8AWQJRYYQs924qRsVVX-SBUsMEeOc4FUaRxipyjfHpcUBiS8eHi_e7p3j5BzBjfMv6nG-oaFIuIHZMyEjALOZXRIxiAAApAyHJETa9cAECUQH5ORECDDRM7GpFsWBWpHTUEr1ajWWG2aUlNbIW6RvinrWq-bTU9NTbfKGqVd6ZUN5qVyprW0rKnJ0CJ97xtsHdZ2pzfKlVg7e0vntPG2DQ5z1nV5f0qOClVZPNv_E_J6t3xZPASr5_vHxXwVaBEJHmitsJgVocwRWMY1FplAHmcolObc5wXJQ6F9cpExoWWuw5mIBQfFkSlQYkKuBl-_wUeH1qWb0mqsKlWj6WzKw4glURwz8OjlH3Rturb223kqjmfAkkR66nqgtI9kWyzSpi03qu1TBumui9R3kX534dmLvWOX-Wv9kj_H98B0AD7LCvv_ndLF8mmw_AJwNJS0</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Salman, Ahmed Abdallah</creator><creator>Salman, Mohamed Abdalla</creator><creator>Shawkat, Mohamed</creator><creator>Hassan, Shady A.</creator><creator>Saad, Eman H.</creator><creator>Hussein, Ahmed Mahmoud</creator><creator>Refaie, Osama R. M.</creator><creator>Tourky, Mohamed Sabry</creator><creator>Shaaban, Hossam El‐Din</creator><creator>Abd Allah, Nesrin</creator><creator>El Domiaty, Heba Fathy</creator><creator>Elkassar, Hesham</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0026-0841</orcidid><orcidid>https://orcid.org/0000-0002-4783-258X</orcidid></search><sort><creationdate>202102</creationdate><title>Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study</title><author>Salman, Ahmed Abdallah ; Salman, Mohamed Abdalla ; Shawkat, Mohamed ; Hassan, Shady A. ; Saad, Eman H. ; Hussein, Ahmed Mahmoud ; Refaie, Osama R. M. ; Tourky, Mohamed Sabry ; Shaaban, Hossam El‐Din ; Abd Allah, Nesrin ; El Domiaty, Heba Fathy ; Elkassar, Hesham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-ccaef9f46de01b2cefb3e27be3ac2235206243c4353b13c6dc4937320a2e1a0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aldosterone</topic><topic>Angiotensin</topic><topic>Angiotensin II</topic><topic>Angiotensinogen</topic><topic>Atrial natriuretic peptide</topic><topic>Blood pressure</topic><topic>Endothelins</topic><topic>Gastrectomy</topic><topic>Hypertension</topic><topic>laparoscopic sleeve gastrectomy</topic><topic>Laparoscopy</topic><topic>Neprilysin</topic><topic>Obesity</topic><topic>Peptides</topic><topic>Remission</topic><topic>Renin</topic><topic>Surgery</topic><topic>Vasoactive agents</topic><topic>vasoactive mediators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salman, Ahmed Abdallah</creatorcontrib><creatorcontrib>Salman, Mohamed Abdalla</creatorcontrib><creatorcontrib>Shawkat, Mohamed</creatorcontrib><creatorcontrib>Hassan, Shady A.</creatorcontrib><creatorcontrib>Saad, Eman H.</creatorcontrib><creatorcontrib>Hussein, Ahmed Mahmoud</creatorcontrib><creatorcontrib>Refaie, Osama R. M.</creatorcontrib><creatorcontrib>Tourky, Mohamed Sabry</creatorcontrib><creatorcontrib>Shaaban, Hossam El‐Din</creatorcontrib><creatorcontrib>Abd Allah, Nesrin</creatorcontrib><creatorcontrib>El Domiaty, Heba Fathy</creatorcontrib><creatorcontrib>Elkassar, Hesham</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salman, Ahmed Abdallah</au><au>Salman, Mohamed Abdalla</au><au>Shawkat, Mohamed</au><au>Hassan, Shady A.</au><au>Saad, Eman H.</au><au>Hussein, Ahmed Mahmoud</au><au>Refaie, Osama R. M.</au><au>Tourky, Mohamed Sabry</au><au>Shaaban, Hossam El‐Din</au><au>Abd Allah, Nesrin</au><au>El Domiaty, Heba Fathy</au><au>Elkassar, Hesham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2021-02</date><risdate>2021</risdate><volume>94</volume><issue>2</issue><spage>193</spage><epage>203</epage><pages>193-203</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Introduction
The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor and vasodilatory molecules in obese hypertensive patients undergoing laparoscopic sleeve gastrectomy (LSG).
Patients
The present prospective study was done on 59 hypertensive obese patients in whom LGS was performed. Blood pressure, as well as blood samples for neprilysin, angiotensinogen, angiotensin II, renin, endothelin‐1 "ET‐1", aldosterone, atrial natriuretic peptide "ANP" and B‐type natriuretic peptide "BNP", were assessed before and 15 months after surgery. Patients were divided into two groups according to the remission of hypertension (HTN).
Results
After 15 months, remission of hypertension was seen in 42 patients (71%). The declines in the following measurements were significantly higher in patients with remission than those with persistent HTN: aldosterone (p = .029567), angiotensin II (p < .000001), angiotensinogen (p = .000021), neprilysin (p = .000601), renin (p = .000454) and endothelin‐1(p = .000030). There was a significantly higher increment in ANP (p = .000002) and a non‐significant increment in BNP (p = .081740). Angiotensin II 15 months after LSG and Δ ANP % were significant independent predictors of persistent HTN.
Conclusion
In the setting of LSG, aldosterone, angiotensinogen, angiotensin II, renin and neprilysin were significantly lower in patients with remission of HTN after 15 months than those with persistent HTN, and natriuretic peptides were significantly higher. A lower postoperative level of angiotensin II and a larger percentage increment of ANP are independently associated with hypertension remission after LSG.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33064869</pmid><doi>10.1111/cen.14352</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0026-0841</orcidid><orcidid>https://orcid.org/0000-0002-4783-258X</orcidid></addata></record> |
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| subjects | Aldosterone Angiotensin Angiotensin II Angiotensinogen Atrial natriuretic peptide Blood pressure Endothelins Gastrectomy Hypertension laparoscopic sleeve gastrectomy Laparoscopy Neprilysin Obesity Peptides Remission Renin Surgery Vasoactive agents vasoactive mediators |
| title | Effect of laparoscopic sleeve gastrectomy on vasoactive mediators in obese hypertensive patients: A prospective study |
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