Association of vitamin D receptor genetic variants with bone mineral density and inflammatory markers in rheumatoid arthritis

Vitamin D receptor (VDR) genetic variants are considered to have a role in the pathogenesis of rheumatoid arthritis (RA). This study examines an association of FokI, BsmI, ApaI and TaqI with RA, as well as with bone mineral density (RA with normal bone mineral density, RA-NBMD; RA with associated os...

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Bibliographic Details
Published in:Clinical biochemistry 2021-01, Vol.87, p.26-31
Main Authors: Despotović, Milena, Jevtović Stoimenov, Tatjana, Stojanović, Sonja, Bašić, Jelena, Kundalić, Jasen, Đorđević, Branka, Ranđelović, Milica, Pavlović, Dušica
Format: Article
Language:English
Subjects:
Bone mineral density
Inflammatory markers
Rheumatoid arthritis
Single nucleotide polymorphism
Vitamin D receptor
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Summary:Vitamin D receptor (VDR) genetic variants are considered to have a role in the pathogenesis of rheumatoid arthritis (RA). This study examines an association of FokI, BsmI, ApaI and TaqI with RA, as well as with bone mineral density (RA with normal bone mineral density, RA-NBMD; RA with associated osteopenia, RA-OSTP; and RA with associated osteoporosis, RA-OP) and inflammatory markers. VDR genetic variants were tested in 248 subjects using the PCR-RFLP method. Significant differences were observed in the distribution of FokI genotypes between RA patients (p 
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2020.10.006