Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models

Asphodelus tenuifolius is traditionally used in the management of rheumatic pain and inflamed body parts. The current study validated its traditional use as an anti-arthritic and anti-inflammatory agent using a series of in vivo models. Carrageenan and histamine-induced acute oedema models were empl...

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Bibliographic Details
Published in:Inflammopharmacology 2021-04, Vol.29 (2), p.483-497
Main Authors: Saleem, Mohammad, Iftikhar, Anam, Asif, Muhammad, Hussain, Khalid, Alamgeer, Shah, Pervaiz Akhtar, Saleem, Ammara, Akhtar, Muhammad Furqan, Tanzeem, Muhammad, Yaseen, Hafiza Sidra
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Gastroenterology
Immunology
Original Article
Pharmacology/Toxicology
Rheumatology
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Summary:Asphodelus tenuifolius is traditionally used in the management of rheumatic pain and inflamed body parts. The current study validated its traditional use as an anti-arthritic and anti-inflammatory agent using a series of in vivo models. Carrageenan and histamine-induced acute oedema models were employed to study the effects of n -hexane ( n-HeAT ) and ethanolic ( EeAT ) extracts on acute inflammatory mediators and were found to inhibit oedema formation in a dose-dependent manner. Formalin and complete Freund’s adjuvant (CFA) were injected into the hind paw of rats for the induction of arthritis. In the formalin model both n-HeAT and EeAT showed significantly better ( p  
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-020-00761-z