Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age. Immunohistochemistry of ALDH1, E-cadherin, Vimentin...

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Bibliographic Details
Published in:Biomarkers in medicine 2020-10, Vol.14 (14), p.1371-1382
Main Authors: Vermani, Litika, Kumar, Rajeev, Kannan, Rengaswamy R, Deka, Monoj K, Talukdar, Anuradha, Kumar, Nachimuthu S
Format: Article
Language:English
Subjects:
Adult
Age
Age of Onset
Aged
Aged, 80 and over
Aldehyde dehydrogenase
Aldehyde Dehydrogenase 1 Family - genetics
Aldehyde Dehydrogenase 1 Family - metabolism
ALDH1
Antibodies
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biopsy
Cadherins - genetics
Cadherins - metabolism
cancer stem cell
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Drug resistance
E-cadherin
epithelial mesenchymal transition
Female
Gene expression
Humans
Immunohistochemistry
Isoenzymes - genetics
Isoenzymes - metabolism
Male
Metastasis
Middle Aged
Mortality
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Overexpression
Patients
Research centers
Retinal Dehydrogenase - genetics
Retinal Dehydrogenase - metabolism
Stem cells
Tumors
twist
Twist-Related Protein 1 - genetics
Twist-Related Protein 1 - metabolism
Vimentin
Vimentin - metabolism
young colorectal cancer
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Summary:To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age. Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples. ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001). High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.
ISSN:1752-0363
1752-0371
1752-0371
DOI:10.2217/bmm-2020-0206