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Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer
To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age. Immunohistochemistry of ALDH1, E-cadherin, Vimentin...
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| Published in: | Biomarkers in medicine 2020-10, Vol.14 (14), p.1371-1382 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c371t-b5c6f6b1591ac3dc1d2b00d7d816f84d2de4c34f8cb419655639a91fc5c266e63 |
| container_end_page | 1382 |
| container_issue | 14 |
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| container_title | Biomarkers in medicine |
| container_volume | 14 |
| creator | Vermani, Litika Kumar, Rajeev Kannan, Rengaswamy R Deka, Monoj K Talukdar, Anuradha Kumar, Nachimuthu S |
| description | To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.
Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.
ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).
High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer. |
| doi_str_mv | 10.2217/bmm-2020-0206 |
| format | article |
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Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.
ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).
High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.</description><identifier>ISSN: 1752-0363</identifier><identifier>ISSN: 1752-0371</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2020-0206</identifier><identifier>PMID: 33064013</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adult ; Age ; Age of Onset ; Aged ; Aged, 80 and over ; Aldehyde dehydrogenase ; Aldehyde Dehydrogenase 1 Family - genetics ; Aldehyde Dehydrogenase 1 Family - metabolism ; ALDH1 ; Antibodies ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biopsy ; Cadherins - genetics ; Cadherins - metabolism ; cancer stem cell ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Drug resistance ; E-cadherin ; epithelial mesenchymal transition ; Female ; Gene expression ; Humans ; Immunohistochemistry ; Isoenzymes - genetics ; Isoenzymes - metabolism ; Male ; Metastasis ; Middle Aged ; Mortality ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Overexpression ; Patients ; Research centers ; Retinal Dehydrogenase - genetics ; Retinal Dehydrogenase - metabolism ; Stem cells ; Tumors ; twist ; Twist-Related Protein 1 - genetics ; Twist-Related Protein 1 - metabolism ; Vimentin ; Vimentin - metabolism ; young colorectal cancer</subject><ispartof>Biomarkers in medicine, 2020-10, Vol.14 (14), p.1371-1382</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Oct 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-b5c6f6b1591ac3dc1d2b00d7d816f84d2de4c34f8cb419655639a91fc5c266e63</citedby><cites>FETCH-LOGICAL-c371t-b5c6f6b1591ac3dc1d2b00d7d816f84d2de4c34f8cb419655639a91fc5c266e63</cites><orcidid>0000-0003-2259-8341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33064013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vermani, Litika</creatorcontrib><creatorcontrib>Kumar, Rajeev</creatorcontrib><creatorcontrib>Kannan, Rengaswamy R</creatorcontrib><creatorcontrib>Deka, Monoj K</creatorcontrib><creatorcontrib>Talukdar, Anuradha</creatorcontrib><creatorcontrib>Kumar, Nachimuthu S</creatorcontrib><title>Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.
Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.
ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).
High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.</description><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aldehyde dehydrogenase</subject><subject>Aldehyde Dehydrogenase 1 Family - genetics</subject><subject>Aldehyde Dehydrogenase 1 Family - metabolism</subject><subject>ALDH1</subject><subject>Antibodies</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>cancer stem cell</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Drug resistance</subject><subject>E-cadherin</subject><subject>epithelial mesenchymal transition</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Isoenzymes - genetics</subject><subject>Isoenzymes - metabolism</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Overexpression</subject><subject>Patients</subject><subject>Research centers</subject><subject>Retinal Dehydrogenase - genetics</subject><subject>Retinal Dehydrogenase - metabolism</subject><subject>Stem cells</subject><subject>Tumors</subject><subject>twist</subject><subject>Twist-Related Protein 1 - genetics</subject><subject>Twist-Related Protein 1 - metabolism</subject><subject>Vimentin</subject><subject>Vimentin - metabolism</subject><subject>young colorectal cancer</subject><issn>1752-0363</issn><issn>1752-0371</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0Eoh9w5IosceHQtP6Inc2xKltaaSUuLVfLGU-Eq8QOtqPSf4-XLT0gcbDsGT1-NZqHkA-cnQvBu4thnhvBBGvq0a_IMe-UaJjs-OuXt5ZH5CTnB8ZU12nxlhxJyXTLuDwmYftrSZizj4EuthRMgcaRXu6-3PAzum3Auh-YfDij3_2MofhAbXD07tHnQmuBNk1Pf1qTLUhjyFhoXmKyzgOFOMWEUOxEwQbA9I68Ge2U8f3zfUrur7d3VzfN7tvX26vLXQN18tIMCvSoB656bkE64E4MjLnObbgeN60TDluQ7biBoeW9VkrL3vZ8BAVCa9TylHw-5C4p_lwxFzP7DDhNNmBcsxGt4hvVM8Uq-ukf9CGuKdTpjFBMVExLWanmQEGKOScczZL8bNOT4czsRZgqwuxFmL2Iyn98Tl2HGd0L_XfzFegPwLiWtRoAj3VB5lDVHx58wP-E_wayF5Yw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Vermani, Litika</creator><creator>Kumar, Rajeev</creator><creator>Kannan, Rengaswamy R</creator><creator>Deka, Monoj K</creator><creator>Talukdar, Anuradha</creator><creator>Kumar, Nachimuthu S</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2259-8341</orcidid></search><sort><creationdate>20201001</creationdate><title>Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer</title><author>Vermani, Litika ; Kumar, Rajeev ; Kannan, Rengaswamy R ; Deka, Monoj K ; Talukdar, Anuradha ; Kumar, Nachimuthu S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-b5c6f6b1591ac3dc1d2b00d7d816f84d2de4c34f8cb419655639a91fc5c266e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aldehyde dehydrogenase</topic><topic>Aldehyde Dehydrogenase 1 Family - genetics</topic><topic>Aldehyde Dehydrogenase 1 Family - metabolism</topic><topic>ALDH1</topic><topic>Antibodies</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>cancer stem cell</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Drug resistance</topic><topic>E-cadherin</topic><topic>epithelial mesenchymal transition</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Isoenzymes - genetics</topic><topic>Isoenzymes - metabolism</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Overexpression</topic><topic>Patients</topic><topic>Research centers</topic><topic>Retinal Dehydrogenase - genetics</topic><topic>Retinal Dehydrogenase - metabolism</topic><topic>Stem cells</topic><topic>Tumors</topic><topic>twist</topic><topic>Twist-Related Protein 1 - genetics</topic><topic>Twist-Related Protein 1 - metabolism</topic><topic>Vimentin</topic><topic>Vimentin - metabolism</topic><topic>young colorectal cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vermani, Litika</creatorcontrib><creatorcontrib>Kumar, Rajeev</creatorcontrib><creatorcontrib>Kannan, Rengaswamy R</creatorcontrib><creatorcontrib>Deka, Monoj K</creatorcontrib><creatorcontrib>Talukdar, Anuradha</creatorcontrib><creatorcontrib>Kumar, Nachimuthu S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vermani, Litika</au><au>Kumar, Rajeev</au><au>Kannan, Rengaswamy R</au><au>Deka, Monoj K</au><au>Talukdar, Anuradha</au><au>Kumar, Nachimuthu S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>14</volume><issue>14</issue><spage>1371</spage><epage>1382</epage><pages>1371-1382</pages><issn>1752-0363</issn><issn>1752-0371</issn><eissn>1752-0371</eissn><abstract>To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.
Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.
ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).
High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>33064013</pmid><doi>10.2217/bmm-2020-0206</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2259-8341</orcidid></addata></record> |
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| subjects | Adult Age Age of Onset Aged Aged, 80 and over Aldehyde dehydrogenase Aldehyde Dehydrogenase 1 Family - genetics Aldehyde Dehydrogenase 1 Family - metabolism ALDH1 Antibodies Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biopsy Cadherins - genetics Cadherins - metabolism cancer stem cell Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug resistance E-cadherin epithelial mesenchymal transition Female Gene expression Humans Immunohistochemistry Isoenzymes - genetics Isoenzymes - metabolism Male Metastasis Middle Aged Mortality Nuclear Proteins - genetics Nuclear Proteins - metabolism Overexpression Patients Research centers Retinal Dehydrogenase - genetics Retinal Dehydrogenase - metabolism Stem cells Tumors twist Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Vimentin Vimentin - metabolism young colorectal cancer |
| title | Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer |
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