Noninvasive DW-MRI metrics for staging hepatic fibrosis and grading inflammatory activity in patients with chronic hepatitis B

Purpose To assess the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging (DWI) models for staging hepatic fibrosis (HF) and grading inflammatory activity in patients with chronic hepatitis B (CHB). Methods 82 patie...

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Bibliographic Details
Published in:Abdominal imaging 2021-05, Vol.46 (5), p.1864-1875
Main Authors: Fu, Fangfang, Li, Xiaodong, Liu, Qiuyu, Chen, Cuiyun, Bai, Yan, Shi, Dapeng, Sang, Jia, Wang, Kaiyu, Wang, Meiyun
Format: Article
Language:English
Subjects:
Diffusion
Diffusion coefficient
Fibrosis
Gastroenterology
Hepatitis
Hepatitis B
Hepatobiliary
Hepatology
Heterogeneity
Imaging
Inflammation
Interferon
Liver
Liver cirrhosis
Magnetic resonance imaging
Mathematical models
Medicine
Medicine & Public Health
Parameters
Perfusion
Radiology
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Summary:Purpose To assess the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging (DWI) models for staging hepatic fibrosis (HF) and grading inflammatory activity in patients with chronic hepatitis B (CHB). Methods 82 patients with CHB and 30 healthy volunteers underwent DWI with 13 b -values on a 3T MRI unit. The standard apparent diffusion coefficient (ADC st ) was calculated using a monoexponential model. The true diffusion coefficient ( D t ), pseudo-diffusion coefficient ( D p ), and perfusion fraction ( f ) were calculated using a biexponential model. The distributed diffusion coefficient (DDC) and water-molecule diffusion heterogeneity index ( α ) were calculated using a stretched-exponential model. Receiver operating characteristic (ROC) curves were performed for diffusion parameters to compare the diagnosis performance. Results The distributions of hepatic fibrosis stages and the inflammatory activity grades (METAVIR scoring system) were as follows: F0, n  = 1; F1, n  = 16; F2, n  = 31; F3, n  = 19; and F4, n  = 15. A0, n  = 1; A1, n  = 14; A2, n  = 46; and A3, n  = 21. ADC st , D t and DDC values showed negative correlation with the fibrosis stage ( r  = − 0.418, − 0.717 and − 0.630, all P  
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-020-02801-2