Ophthalmic artery Doppler in combination with other biomarkers in prediction of pre‐eclampsia at 35–37 weeks' gestation

ABSTRACT Objective To examine the potential value of maternal ophthalmic artery Doppler at 35–37 weeks' gestation in combination with the established biomarkers of pre‐eclampsia (PE), including mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI), serum placental growth facto...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2021-04, Vol.57 (4), p.600-606
Main Authors: Sarno, M., Wright, A., Vieira, N., Sapantzoglou, I., Charakida, M., Nicolaides, K. H.
Format: Article
Language:English
Subjects:
Adult
Arterial Pressure
Biomarkers - blood
Female
Gestational Age
Humans
Maternal Serum Screening Tests - statistics & numerical data
Ophthalmic Artery - diagnostic imaging
Ophthalmic Artery - physiopathology
ophthalmic artery Doppler
Placenta Growth Factor - blood
Pre-Eclampsia - diagnosis
prediction
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Third - blood
pre‐eclampsia
Prospective Studies
Pulsatile Flow
third trimester
Ultrasonography, Doppler - methods
Ultrasonography, Doppler - statistics & numerical data
Ultrasonography, Prenatal - methods
Ultrasonography, Prenatal - statistics & numerical data
Uterine Artery - diagnostic imaging
Uterine Artery - physiopathology
Vascular Endothelial Growth Factor Receptor-1 - blood
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Summary:ABSTRACT Objective To examine the potential value of maternal ophthalmic artery Doppler at 35–37 weeks' gestation in combination with the established biomarkers of pre‐eclampsia (PE), including mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI), serum placental growth factor (PlGF) and serum soluble fms‐like tyrosine kinase‐1 (sFlt‐1), in the prediction of subsequent development of PE. Methods This was a prospective observational study in women attending for a routine hospital visit at 35 + 0 to 36 + 6 weeks' gestation. This visit included recording of maternal demographic characteristics and medical history, ultrasound examination for fetal anatomy and growth, assessment of flow velocity waveforms from the maternal ophthalmic arteries, and measurement of MAP, UtA‐PI, serum PlGF and serum sFlt‐1. The competing‐risks model was used to estimate the individual patient‐specific risks of delivery with PE at any time and at
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.23517