Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial

Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for...

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Bibliographic Details
Published in:The American journal of emergency medicine 2021-08, Vol.46, p.188-192
Main Authors: Zolfaghari Sadrabad, Akram, Azimi Abarghouei, Soheila, Farahmand Rad, Reza, Salimi, Yahya
Format: Article
Language:English
Subjects:
Analgesics
Blood pressure
Clinical trials
Drugs
Emergency medical care
Intravenous administration
Kidney stones
Kidneys
Lithiasis
Magnesium sulfate
Morphine
Nausea
Nephrolithiasis
Nervous system
Pain
Pain management
Patients
Randomized controlled trial
Renal colic
Side effects
Sulfates
Vomiting
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Summary:Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for analgesic effect as well as lack of morphine sulfate side effects when using magnesium sulfate. We conducted a double-blind randomized clinical trial in renal colic patients who had referred to the emergency department of Shahid Sadoughi Hospital in Yazd, Iran. A total of 80 eligible patients were selected and randomly assigned into two groups; patients in the case group received 50 mg/kg intravenous magnesium sulfate, and those in the control group 0.1 mg/kg intravenous morphine. The primary outcome was the pain score measured on a numerical rating scale at 0, 10 and 20 minutes after infusion. Data were analyzed using SPSS16. The two groups were similar in terms of demographic features and pain intensity at the time of referral (P 
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2020.07.035