Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats

In the present study it has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zinc) during perinatal period reduces the expression of genetic absence epilepsy and comorbid depression in adult offspring of WAG/Rij rats. This ben...

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Bibliographic Details
Published in:Doklady. Biological sciences 2020-09, Vol.494 (1), p.244-247
Main Authors: Sarkisova, K. Yu, Gabova, A. V., Fedosova, E. A., Shatskova, A. B.
Format: Article
Language:English
Subjects:
Betaine
Biomedical and Life Sciences
Choline
Comorbidity
Diet
Epigenetics
Epilepsy
Evolutionary Biology
Folic acid
General Biology
Life Sciences
Methionine
Phenotypes
Plant Sciences
Vitamin B12
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Summary:In the present study it has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zinc) during perinatal period reduces the expression of genetic absence epilepsy and comorbid depression in adult offspring of WAG/Rij rats. This beneficial effect was more pronounced in males compared with females. It is assumed that epigenetic modifications induced by maternal methyl-enriched diet in the offspring at the early stages of ontogenesis might be a possible mechanism underlying the correction of genetically-based pathologic phenotype in WAG/Rij rats. Results suggest that methyl-enriched diet during perinatal period can be potentially used for mitigation or prevention epileptogenesis and depression-like comorbid disorders in people genetically predisposed to absence epilepsy.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496620050075